Gdf16, a novel member of the growth/differentiation factor subgroup of the TGF-β superfamily, is expressed in the hindbrain and epibranchial placodes

Steven A. Vokes, Paul A Krieg

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

We have isolated and characterized the developmental expression of Xenopus gdf16, a novel member of the growth/differentiation factor (gdf) gene family. The gdf16 gene encodes a pre-proprotein of 413 amino acids and a mature peptide of 122 amino acids. Gdf16 is most closely related to the zebrafish genes dynamo and radar, but exhibits a completely different expression pattern. Gene expression is detected at early tailbud (stage 25) in the first two epibranchial placodes and in a hindbrain-specific domain. As development proceeds, the gene is expressed in all the epibranchial placodes, the hindbrain, and the diencephalon. Copyright (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish (US)
Pages (from-to)279-282
Number of pages4
JournalMechanisms of Development
Volume95
Issue number1-2
DOIs
StatePublished - Jul 1 2000

Fingerprint

Growth Differentiation Factors
Rhombencephalon
Genes
Radar
Amino Acids
Diencephalon
Zebrafish
Xenopus
Gene Expression
Peptides

Keywords

  • Diencephalon
  • Epibranchial placodes
  • Gdf16
  • Growth/differentiation factor
  • Hindbrain
  • TGF-β

ASJC Scopus subject areas

  • Developmental Biology
  • Developmental Neuroscience

Cite this

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abstract = "We have isolated and characterized the developmental expression of Xenopus gdf16, a novel member of the growth/differentiation factor (gdf) gene family. The gdf16 gene encodes a pre-proprotein of 413 amino acids and a mature peptide of 122 amino acids. Gdf16 is most closely related to the zebrafish genes dynamo and radar, but exhibits a completely different expression pattern. Gene expression is detected at early tailbud (stage 25) in the first two epibranchial placodes and in a hindbrain-specific domain. As development proceeds, the gene is expressed in all the epibranchial placodes, the hindbrain, and the diencephalon. Copyright (C) 2000 Elsevier Science Ireland Ltd.",
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