Gender and racial differences in nonalcoholic fatty liver disease

Jen Jung Pan, Michael B. Fallon

Research output: Contribution to journalArticle

130 Scopus citations

Abstract

Due to the worldwide epidemic of obesity, nonalcoholic fatty liver disease (NAFLD) has become the most common cause of elevated liver enzymes. NAFLD represents a spectrum of liver injury ranging from simple steatosis to nonalcoholic steatohepatitis (NASH) which may progress to advanced fibrosis and cirrhosis. Individuals with NAFLD, especially those with metabolic syndrome, have higher overall mortality, cardiovascular mortality, and liver-related mortality compared with the general population. According to the population-based studies, NAFLD and NASH are more prevalent in males and in Hispanics. Both the gender and racial ethnic differences in NAFLD and NASH are likely attributed to interaction between environmental, behavioral, and genetic factors. Using genome-wide association studies, several genetic variants have been identified to be associated with NAFLD/NASH. However, these variants account for only a small amount of variation in hepatic steatosis among ethnic groups and may serve as modifiers of the natural history of NAFLD. Alternatively, these variants may not be the causative variants but simply markers representing a larger body of genetic variations. In this article, we provide a concise review of the gender and racial differences in the prevalence of NAFLD and NASH in adults. We also discuss the possible mechanisms for these disparities.

Original languageEnglish (US)
Pages (from-to)274-283
Number of pages10
JournalWorld Journal of Hepatology
Volume6
Issue number5
DOIs
StatePublished - May 2014
Externally publishedYes

Keywords

  • Gender
  • Genetic polymorphism
  • Nonalcoholic fatty liver disease
  • Nonalcoholic steatohepatitis
  • Prevalence
  • Race

ASJC Scopus subject areas

  • Hepatology

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