Gene expression in aminergic and peptidergic cells during aggression and defeat: Relevance to violence, depression and drug abuse

Klaus A. Miczek, Ella M Nikulina, Aki Takahashi, Herbert E. Covington, Jasmine J. Yap, Christopher O. Boyson, Akiko Shimamoto, Rosa M M De Almeida

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

In this review, we examine how experiences in social confrontations alter gene expression in mesocorticolimbic cells. The focus is on the target of attack and threat due to the prominent role of social defeat stress in the study of coping mechanisms and victimization. The initial operational definition of the socially defeated mouse by Ginsburg and Allee (1942) enabled the characterization of key endocrine, cardiovascular, and metabolic events during the initial response to an aggressive opponent and during the ensuing adaptations. Brief episodes of social defeat stress induce an augmented response to stimulant challenge as reflected by increased locomotion and increased extracellular dopamine (DA) in the nucleus accumbens (NAC). Cells in the ventral tegmental area (VTA) that project to the NAC were more active as indicated by increased expression of c-fos and Fosimmunoreactivity and BDNF. Intermittent episodes of social defeat stress result in increased mRNA for MOR in brainstem and limbic structures. These behavioral and neurobiological indices of sensitization persist for several months after the stress experience. The episodically defeated rats also self-administered intravenous cocaine during continuous access for 24 h ("binge"). By contrast, continuous social stress, particularly in the form of social subordination stress, leads to reduced appetite, compromised endocrine activities, and cardiovascular and metabolic abnormalities, and prefer sweets less as index of anhedonia. Cocaine challenges in subordinate rats result in a blunted psychomotor stimulant response and a reduced DA release in NAC. Subordinate rats self-administer cocaine less during continuous access conditions. These contrasting patterns of social stress result from continuous vs. intermittent exposure to social stress, suggesting divergent neuroadaptations for increased vulnerability to cocaine self-administration vs. deteriorated reward mechanisms characteristic of depressive-like profiles.

Original languageEnglish (US)
Pages (from-to)787-802
Number of pages16
JournalBehavior Genetics
Volume41
Issue number6
DOIs
StatePublished - Nov 2011

Fingerprint

drug abuse
cocaine
violence
aggression
Aggression
Cocaine
Violence
gene expression
Substance-Related Disorders
Nucleus Accumbens
Depression
Gene Expression
dopamine
Dopamine
rats
cells
Cardiovascular Abnormalities
Anhedonia
coping strategies
Ventral Tegmental Area

Keywords

  • Amphetamine
  • Anhedonia
  • Cocaine
  • Defeat
  • Dorsal raphe
  • Sensitization
  • Social stress
  • Tolerance
  • Ventral tegmental area

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)
  • Ecology, Evolution, Behavior and Systematics

Cite this

Gene expression in aminergic and peptidergic cells during aggression and defeat : Relevance to violence, depression and drug abuse. / Miczek, Klaus A.; Nikulina, Ella M; Takahashi, Aki; Covington, Herbert E.; Yap, Jasmine J.; Boyson, Christopher O.; Shimamoto, Akiko; De Almeida, Rosa M M.

In: Behavior Genetics, Vol. 41, No. 6, 11.2011, p. 787-802.

Research output: Contribution to journalArticle

Miczek, KA, Nikulina, EM, Takahashi, A, Covington, HE, Yap, JJ, Boyson, CO, Shimamoto, A & De Almeida, RMM 2011, 'Gene expression in aminergic and peptidergic cells during aggression and defeat: Relevance to violence, depression and drug abuse', Behavior Genetics, vol. 41, no. 6, pp. 787-802. https://doi.org/10.1007/s10519-011-9462-5
Miczek, Klaus A. ; Nikulina, Ella M ; Takahashi, Aki ; Covington, Herbert E. ; Yap, Jasmine J. ; Boyson, Christopher O. ; Shimamoto, Akiko ; De Almeida, Rosa M M. / Gene expression in aminergic and peptidergic cells during aggression and defeat : Relevance to violence, depression and drug abuse. In: Behavior Genetics. 2011 ; Vol. 41, No. 6. pp. 787-802.
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