Gene-nutrient interactions in nutritional epidemiology

Lenore Kohlmeier, David DeMarini, Walter W Piegorsch

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

There is increasing evidence that the ways in which nutrients are handled metabolically is, to a greater or lesser extent, under genetic control. Equally, nutrient (and non-nutrient) intakes affect the expression of genetic predispositions. These complex interactions (nutrient regulation of gene transcription, food-induced DNA damage, phytochemical enhancement or protection of DNA integrity, genetic susceptibility to nutrition-related diseases) increasingly shed light on epidemiological relationships between diet and health and disease. This chapter considers design and analytical implications for understanding gene-nutrient interactions, including specific statistical models. It concludes with a discussion of ethical issues, and an appendix for sample size determination in relation to the determination of genetic characteristics in nutritional epidemiological studies.

Original languageEnglish (US)
Title of host publicationDesign Concepts in Nutritional Epidemiology
PublisherOxford University Press
ISBN (Print)9780191723704, 9780192627391
DOIs
StatePublished - Sep 1 2009
Externally publishedYes

Fingerprint

Epidemiology
Food
Genes
Genetic Predisposition to Disease
Phytochemicals
Statistical Models
Ethics
Sample Size
DNA Damage
Epidemiologic Studies
Diet
DNA
Health

Keywords

  • Dna damage
  • Dna integrity
  • Ethics
  • Gene-nutrient interactions
  • Genetics
  • Sample size

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Kohlmeier, L., DeMarini, D., & Piegorsch, W. W. (2009). Gene-nutrient interactions in nutritional epidemiology. In Design Concepts in Nutritional Epidemiology Oxford University Press. https://doi.org/10.1093/acprof:oso/9780192627391.003.0011

Gene-nutrient interactions in nutritional epidemiology. / Kohlmeier, Lenore; DeMarini, David; Piegorsch, Walter W.

Design Concepts in Nutritional Epidemiology. Oxford University Press, 2009.

Research output: Chapter in Book/Report/Conference proceedingChapter

Kohlmeier, L, DeMarini, D & Piegorsch, WW 2009, Gene-nutrient interactions in nutritional epidemiology. in Design Concepts in Nutritional Epidemiology. Oxford University Press. https://doi.org/10.1093/acprof:oso/9780192627391.003.0011
Kohlmeier L, DeMarini D, Piegorsch WW. Gene-nutrient interactions in nutritional epidemiology. In Design Concepts in Nutritional Epidemiology. Oxford University Press. 2009 https://doi.org/10.1093/acprof:oso/9780192627391.003.0011
Kohlmeier, Lenore ; DeMarini, David ; Piegorsch, Walter W. / Gene-nutrient interactions in nutritional epidemiology. Design Concepts in Nutritional Epidemiology. Oxford University Press, 2009.
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