Gene therapy for renal disorders

Yeong Hau H Lien, Li-Wen Lai

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

During the last 20 years there have been major improvements in renal replacement therapy, including dialysis and kidney transplantation; however, the treatment options for renal diseases are still limited. Gene therapy is a potential modality for many renal diseases for which we are as yet unable to offer specific treatment. This article reviews the recent data on gene therapy in animal models applicable to human renal diseases and evaluates its efficacy, safety and clinical relevance. Several approaches appear to be promising, including adeno-associated viral vectors for long-term gene expression, electroporation for muscular gene delivery, ultrasound/microbubble-mediated gene targeting, macrophage-based gene therapy and small interfering RNAs.

Original languageEnglish (US)
Pages (from-to)919-926
Number of pages8
JournalExpert Opinion on Biological Therapy
Volume4
Issue number6
DOIs
StatePublished - Jun 2004

Fingerprint

Gene therapy
Genetic Therapy
Kidney
Genes
Microbubbles
Electroporation
Renal Replacement Therapy
Dialysis
Gene Targeting
Macrophages
Gene expression
Kidney Transplantation
Small Interfering RNA
Animals
Animal Models
Ultrasonics
Safety
Gene Expression
Therapeutics

Keywords

  • Acute tubular necrosis
  • Gene therapy
  • Glomerulonephritis
  • Hereditary renal diseases
  • Kidney transplantation
  • Tubulointerstitial fibrosis

ASJC Scopus subject areas

  • Pharmacology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Genetics
  • Immunology

Cite this

Gene therapy for renal disorders. / Lien, Yeong Hau H; Lai, Li-Wen.

In: Expert Opinion on Biological Therapy, Vol. 4, No. 6, 06.2004, p. 919-926.

Research output: Contribution to journalArticle

Lien, Yeong Hau H ; Lai, Li-Wen. / Gene therapy for renal disorders. In: Expert Opinion on Biological Therapy. 2004 ; Vol. 4, No. 6. pp. 919-926.
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