Genealogical correspondence of a forebrain centre implies an executive brain in the protostome-deuterostome bilaterian ancestor

Gabriella H. Wolff, Nicholas J Strausfeld

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Orthologous genes involved in the formation of proteins associated with memory acquisition are similarly expressed in forebrain centres that exhibit similar cognitive properties. These proteins include cAMP-dependent protein kinase A catalytic subunit (PKA-Cα) and phosphorylated Ca2+/calmodulindependent protein kinase II (pCaMKII), both required for long-term memory formation which is enriched in rodent hippocampus and insect mushroom bodies, both implicated in allocentric memory and both possessing corresponding neuronal architectures. Antibodies against these proteins resolve forebrain centres, or their equivalents, having the same ground pattern of neuronal organization in species across five phyla. The ground pattern is defined by olfactory or chemosensory afferents supplying systems of parallel fibres of intrinsic neurons intersected by orthogonal domains of afferent and efferent arborizations with local interneurons providing feedback loops. The totality of shared characters implies a deep origin in the protostome-deuterostome bilaterian ancestor of elements of a learning and memory circuit. Proxies for such an ancestral taxon are simple extant bilaterians, particularly acoels that express PKA-Cα and pCαMKII in discrete anterior domains that can be properly referred to as brains.

Original languageEnglish (US)
Article number20150055
JournalPhilosophical transactions of the Royal Society of London. Series B: Biological sciences
Volume371
Issue number1685
DOIs
StatePublished - Jan 5 2016

Fingerprint

Prosencephalon
Cyclic AMP-Dependent Protein Kinases
ancestry
cAMP-dependent protein kinase
brain
Brain
Data storage equipment
protein
Catalytic Domain
protein subunits
Mushroom Bodies
Proteins
Long-Term Memory
Proxy
Interneurons
mushroom bodies
Protein Kinases
Insects
proteins
Rodentia

Keywords

  • Convergence
  • Evolution
  • Hippocampus
  • Homology
  • Mushroom body

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

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