Genealogical correspondence of mushroom bodies across invertebrate phyla

Gabriella H. Wolff, Nicholas J Strausfeld

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Except in species that have undergone evolved loss, paired lobed centers referred to as "mushroom bodies" occur across invertebrate phyla [1-5]. Unresolved is the question of whether these centers, which support learning and memory in insects, correspond genealogically or whether their neuronal organization suggests convergent evolution. Here, anatomical and immunohistological observations demonstrate that across phyla, mushroom body-like centers share a neuroanatomical ground pattern and proteins required for memory formation. Paired lobed or dome-like neuropils characterize the first brain segment (protocerebrum) of mandibulate and chelicerate arthropods and the nonganglionic brains of polychaete annelids, polyclad planarians, and nemerteans. Structural and cladistic analyses resolve an ancestral ground pattern common to all investigated taxa: chemosensory afferents supplying thousands of intrinsic neurons, the parallel processes of which establish orthogonal networks with feedback loops, modulatory inputs, and efferents. Shared ground patterns and their selective labeling with antisera against proteins required for normal mushroom body function in Drosophila are indicative of genealogical correspondence and thus an ancestral presence predating arthropod and lophotrochozoan origins. Implications of this are considered in the context of mushroom body function and early ecologies of ancestral bilaterians.

Original languageEnglish (US)
Pages (from-to)38-44
Number of pages7
JournalCurrent Biology
Volume25
Issue number1
DOIs
StatePublished - Jan 5 2015

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Mushroom Bodies
mushroom bodies
Invertebrates
Brain
invertebrates
Data storage equipment
Arthropods
Domes
Ecology
brain
Labeling
Neurons
arthropods
Immune Sera
Proteins
Planarians
Feedback
Neuropil
convergent evolution
Annelida

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Genealogical correspondence of mushroom bodies across invertebrate phyla. / Wolff, Gabriella H.; Strausfeld, Nicholas J.

In: Current Biology, Vol. 25, No. 1, 05.01.2015, p. 38-44.

Research output: Contribution to journalArticle

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