General method for the synthesis of N-methyl amino acids and N-alkyl amino esters from O'Donnell's Schiff bases

Jason J. Chruma, Dalibor Sames, Robin Polt

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

N-methyl amino acids, including L-abrine, and N-alkyl amino esters, were synthesized by reductive amination of O'Donnell's Schiff base amino esters with NaBH3CN and formaldehyde, or the appropriate aldehyde in CH3CN or THF in good to excellent yields, and with high purity.

Original languageEnglish (US)
Pages (from-to)5085-5086
Number of pages2
JournalTetrahedron Letters
Volume38
Issue number29
DOIs
StatePublished - Jul 21 1997

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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