General method for the synthesis of N-methyl amino acids and N-alkyl amino esters from O'Donnell's Schiff bases

Jason J. Chruma, Dalibor Sames, Robin L Polt

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

N-methyl amino acids, including L-abrine, and N-alkyl amino esters, were synthesized by reductive amination of O'Donnell's Schiff base amino esters with NaBH3CN and formaldehyde, or the appropriate aldehyde in CH3CN or THF in good to excellent yields, and with high purity.

Original languageEnglish (US)
Pages (from-to)5085-5086
Number of pages2
JournalTetrahedron Letters
Volume38
Issue number29
DOIs
StatePublished - Jul 21 1997

Fingerprint

Schiff Bases
Esters
Amination
Amino Acids
Aldehydes
Formaldehyde
abrine

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

General method for the synthesis of N-methyl amino acids and N-alkyl amino esters from O'Donnell's Schiff bases. / Chruma, Jason J.; Sames, Dalibor; Polt, Robin L.

In: Tetrahedron Letters, Vol. 38, No. 29, 21.07.1997, p. 5085-5086.

Research output: Contribution to journalArticle

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