Generation of lipoxygenase products in the avascular tissues of the eye

Richard N. Williams, Nicholas A Delamere, Christopher A. Paterson

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

We have examined the ability of the avascular cornea and lens to generate lipoxygenase products from arachidonic acid. The cornea and lens were obtained from rabbit and frog eyes, and their ability to metabolize exogenous [14C]-arachidonic acid determined in vitro. The cornea of rabbits and frogs formed lipoxygenase products from arachidonic acid. Both rabbit and frog corneas were found to generate considerable quantities of 12-HETE, although other lipoxygenase products were also produced. In contrast, no lipoxygenase products were detected following incubations of rabbit or frog lens with arachidonic acid. Thus, the cornea and lens, the two avascular tissues in the eye, exhibit marked differences in their ability to metabolize arachidonic acid via lipoxygenase enzymes.

Original languageEnglish (US)
Pages (from-to)733-738
Number of pages6
JournalExperimental Eye Research
Volume41
Issue number6
DOIs
StatePublished - 1985
Externally publishedYes

Fingerprint

Lipoxygenase
Cornea
Arachidonate Lipoxygenases
Anura
Lenses
Rabbits
Arachidonic Acid
12-Hydroxy-5,8,10,14-eicosatetraenoic Acid
Enzymes

Keywords

  • arachidonic acid
  • cornea
  • lens
  • lipoxygenase

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

Cite this

Generation of lipoxygenase products in the avascular tissues of the eye. / Williams, Richard N.; Delamere, Nicholas A; Paterson, Christopher A.

In: Experimental Eye Research, Vol. 41, No. 6, 1985, p. 733-738.

Research output: Contribution to journalArticle

Williams, Richard N. ; Delamere, Nicholas A ; Paterson, Christopher A. / Generation of lipoxygenase products in the avascular tissues of the eye. In: Experimental Eye Research. 1985 ; Vol. 41, No. 6. pp. 733-738.
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