Generation of the [NiFe] hydrogenase active site (sulfur's the one!)

Richard S. Glass, Athanasios Paschos, Stephanie Reissmann, M. S. Singh, Haofan Wang, August Böck

Research output: Contribution to journalArticle

3 Scopus citations


Chemical and biochemical methods were used to unravel the unprecedented pathway by which the CN ligands of iron in [NiFe] hydrogenase are introduced. Carbamoyl phosphate is the one carbon precursor of these ligands, and reactions involving a protein cysteinyl sulfur are key for processing this precursor into CN ligands.

Original languageEnglish (US)
Pages (from-to)1183-1185
Number of pages3
JournalPhosphorus, Sulfur and Silicon and the Related Elements
Issue number5-6
StatePublished - Jan 1 2005



  • Carbamoyl phosphate
  • Thiocarbamate, thiocyanate
  • [NiFe] hydrogenase biosynthesis

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Inorganic Chemistry

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