Genes involved in the thermal tolerance of livestock

Robert J Collier, Kifle Gebremedhin, Antoni R. Macko, Kajal Sankar Roy

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Citations (Scopus)

Abstract

Although there is a good amount of knowledge about the physiological aspects, the effects of heat stress at the cellular and genetic level still remain unrevealed. Functional genomics research is providing new knowledge about the impact of heat stress on livestock production and reproduction. Using functional genomics to identify genes that are up- or down-regulated during a stressful event can lead to the identification of animals that are genetically superior for coping with stress and toward the creation of therapeutic drugs and treatments that target affected genes. Given the complexity of the traits related to adaptation to tropical environments, the discovery of genes controlling these traits is a very difficult task. With the development of molecular biotechnologies, new opportunities are available to characterize gene expression and identify key cellular responses to heat stress. These new tools will enable to improve the accuracy and the efficiency of selection for heat tolerance. Studies evaluating genes identified as participating in the cellular acclimation response from microarray analyses or genome-wide association studies have indicated that heat shock proteins are playing a major role in adaptation to thermal stress. Additional genes of interest which two or more studies have identified are the genes for fibroblast growth factor, solute carrier proteins, interluekins, and tick resistance genes. Genes which have only been identified by microarray analysis but not by genome-wide association studies include genes associated with cellular metabolism (phosphofructo kinase, isocitrate dehydrogenase, NADH dehydrogenase, glycosyltransferase, transcription factor, and mitochondrial inositol protein). Other genes of importance were thyroid hormone receptor, insulin-like growth factor II, and annexin.

Original languageEnglish (US)
Title of host publicationEnvironmental Stress and Amelioration in Livestock Production
PublisherSpringer-Verlag Berlin Heidelberg
Pages379-410
Number of pages32
Volume9783642292057
ISBN (Print)9783642292057, 3642292046, 9783642292040
DOIs
StatePublished - Aug 1 2012

Fingerprint

Livestock
heat tolerance
livestock
tolerance
gene
Genes
genes
heat stress
Hot Temperature
Genome-Wide Association Study
Microarray Analysis
Genomics
protein
genomics
genome
Annexins
Thermotolerance
NADH Dehydrogenase
Heat-Shock Response
Thyroid Hormone Receptors

Keywords

  • Acclimation
  • Functional genomics
  • Heat stress
  • Thermal tolerance

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Environmental Science(all)

Cite this

Collier, R. J., Gebremedhin, K., Macko, A. R., & Roy, K. S. (2012). Genes involved in the thermal tolerance of livestock. In Environmental Stress and Amelioration in Livestock Production (Vol. 9783642292057, pp. 379-410). Springer-Verlag Berlin Heidelberg. https://doi.org/10.1007/978-3-642-29205-7_14

Genes involved in the thermal tolerance of livestock. / Collier, Robert J; Gebremedhin, Kifle; Macko, Antoni R.; Roy, Kajal Sankar.

Environmental Stress and Amelioration in Livestock Production. Vol. 9783642292057 Springer-Verlag Berlin Heidelberg, 2012. p. 379-410.

Research output: Chapter in Book/Report/Conference proceedingChapter

Collier, RJ, Gebremedhin, K, Macko, AR & Roy, KS 2012, Genes involved in the thermal tolerance of livestock. in Environmental Stress and Amelioration in Livestock Production. vol. 9783642292057, Springer-Verlag Berlin Heidelberg, pp. 379-410. https://doi.org/10.1007/978-3-642-29205-7_14
Collier RJ, Gebremedhin K, Macko AR, Roy KS. Genes involved in the thermal tolerance of livestock. In Environmental Stress and Amelioration in Livestock Production. Vol. 9783642292057. Springer-Verlag Berlin Heidelberg. 2012. p. 379-410 https://doi.org/10.1007/978-3-642-29205-7_14
Collier, Robert J ; Gebremedhin, Kifle ; Macko, Antoni R. ; Roy, Kajal Sankar. / Genes involved in the thermal tolerance of livestock. Environmental Stress and Amelioration in Livestock Production. Vol. 9783642292057 Springer-Verlag Berlin Heidelberg, 2012. pp. 379-410
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