Genetic admixture, social-behavioural factors and body composition are associated with blood pressure differently by racial-ethnic group among children

Yann C Klimentidis, A. Dulin-Keita, K. Casazza, A. L. Willig, D. B. Allison, J. R. Fernandez

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Cardiovascular disease has a progressively earlier age of onset, and disproportionately affects African Americans (AAs) in the United States. It has been difficult to establish the extent to which group differences are due to physiological, genetic, social or behavioural factors. In this study, we examined the association between blood pressure and these factors among a sample of 294 children, identified as AA, European American or Hispanic American. We use body composition, behavioural (diet and physical activity) and survey-based measures (socio-economic status and perceived racial discrimination), as well as genetic admixture based on 142 ancestry informative markers (AIMs) to examine associations with systolic and diastolic blood pressure. We find that associations differ by ethnic/racial group. Notably, among AAs, physical activity and perceived racial discrimination, but not African genetic admixture, are associated with blood pressure, while the association between blood pressure and body fat is nearly absent. We find an association between blood pressure and an AIM near a marker identified by a recent genome-wide association study. Our findings shed light on the differences in risk factors for elevated blood pressure among ethnic/racial groups, and the importance of including social and behavioural measures to grasp the full genetic/environmental aetiology of disparities in blood pressure.

Original languageEnglish (US)
Pages (from-to)98-107
Number of pages10
JournalJournal of Human Hypertension
Volume26
Issue number2
DOIs
StatePublished - Feb 2012
Externally publishedYes

Fingerprint

Body Composition
Ethnic Groups
Blood Pressure
African Americans
Racism
Exercise
Genome-Wide Association Study
Age of Onset
Hispanic Americans
Adipose Tissue
Cardiovascular Diseases
Economics
Diet

Keywords

  • blood pressure
  • children
  • genetic admixture
  • racial/ethnic disparities
  • social and behavioural risk factors

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Genetic admixture, social-behavioural factors and body composition are associated with blood pressure differently by racial-ethnic group among children. / Klimentidis, Yann C; Dulin-Keita, A.; Casazza, K.; Willig, A. L.; Allison, D. B.; Fernandez, J. R.

In: Journal of Human Hypertension, Vol. 26, No. 2, 02.2012, p. 98-107.

Research output: Contribution to journalArticle

@article{a5f3855c323b43a39f7881655aa51455,
title = "Genetic admixture, social-behavioural factors and body composition are associated with blood pressure differently by racial-ethnic group among children",
abstract = "Cardiovascular disease has a progressively earlier age of onset, and disproportionately affects African Americans (AAs) in the United States. It has been difficult to establish the extent to which group differences are due to physiological, genetic, social or behavioural factors. In this study, we examined the association between blood pressure and these factors among a sample of 294 children, identified as AA, European American or Hispanic American. We use body composition, behavioural (diet and physical activity) and survey-based measures (socio-economic status and perceived racial discrimination), as well as genetic admixture based on 142 ancestry informative markers (AIMs) to examine associations with systolic and diastolic blood pressure. We find that associations differ by ethnic/racial group. Notably, among AAs, physical activity and perceived racial discrimination, but not African genetic admixture, are associated with blood pressure, while the association between blood pressure and body fat is nearly absent. We find an association between blood pressure and an AIM near a marker identified by a recent genome-wide association study. Our findings shed light on the differences in risk factors for elevated blood pressure among ethnic/racial groups, and the importance of including social and behavioural measures to grasp the full genetic/environmental aetiology of disparities in blood pressure.",
keywords = "blood pressure, children, genetic admixture, racial/ethnic disparities, social and behavioural risk factors",
author = "Klimentidis, {Yann C} and A. Dulin-Keita and K. Casazza and Willig, {A. L.} and Allison, {D. B.} and Fernandez, {J. R.}",
year = "2012",
month = "2",
doi = "10.1038/jhh.2010.130",
language = "English (US)",
volume = "26",
pages = "98--107",
journal = "Journal of Human Hypertension",
issn = "0950-9240",
publisher = "Nature Publishing Group",
number = "2",

}

TY - JOUR

T1 - Genetic admixture, social-behavioural factors and body composition are associated with blood pressure differently by racial-ethnic group among children

AU - Klimentidis, Yann C

AU - Dulin-Keita, A.

AU - Casazza, K.

AU - Willig, A. L.

AU - Allison, D. B.

AU - Fernandez, J. R.

PY - 2012/2

Y1 - 2012/2

N2 - Cardiovascular disease has a progressively earlier age of onset, and disproportionately affects African Americans (AAs) in the United States. It has been difficult to establish the extent to which group differences are due to physiological, genetic, social or behavioural factors. In this study, we examined the association between blood pressure and these factors among a sample of 294 children, identified as AA, European American or Hispanic American. We use body composition, behavioural (diet and physical activity) and survey-based measures (socio-economic status and perceived racial discrimination), as well as genetic admixture based on 142 ancestry informative markers (AIMs) to examine associations with systolic and diastolic blood pressure. We find that associations differ by ethnic/racial group. Notably, among AAs, physical activity and perceived racial discrimination, but not African genetic admixture, are associated with blood pressure, while the association between blood pressure and body fat is nearly absent. We find an association between blood pressure and an AIM near a marker identified by a recent genome-wide association study. Our findings shed light on the differences in risk factors for elevated blood pressure among ethnic/racial groups, and the importance of including social and behavioural measures to grasp the full genetic/environmental aetiology of disparities in blood pressure.

AB - Cardiovascular disease has a progressively earlier age of onset, and disproportionately affects African Americans (AAs) in the United States. It has been difficult to establish the extent to which group differences are due to physiological, genetic, social or behavioural factors. In this study, we examined the association between blood pressure and these factors among a sample of 294 children, identified as AA, European American or Hispanic American. We use body composition, behavioural (diet and physical activity) and survey-based measures (socio-economic status and perceived racial discrimination), as well as genetic admixture based on 142 ancestry informative markers (AIMs) to examine associations with systolic and diastolic blood pressure. We find that associations differ by ethnic/racial group. Notably, among AAs, physical activity and perceived racial discrimination, but not African genetic admixture, are associated with blood pressure, while the association between blood pressure and body fat is nearly absent. We find an association between blood pressure and an AIM near a marker identified by a recent genome-wide association study. Our findings shed light on the differences in risk factors for elevated blood pressure among ethnic/racial groups, and the importance of including social and behavioural measures to grasp the full genetic/environmental aetiology of disparities in blood pressure.

KW - blood pressure

KW - children

KW - genetic admixture

KW - racial/ethnic disparities

KW - social and behavioural risk factors

UR - http://www.scopus.com/inward/record.url?scp=84855847692&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84855847692&partnerID=8YFLogxK

U2 - 10.1038/jhh.2010.130

DO - 10.1038/jhh.2010.130

M3 - Article

C2 - 21248781

AN - SCOPUS:84855847692

VL - 26

SP - 98

EP - 107

JO - Journal of Human Hypertension

JF - Journal of Human Hypertension

SN - 0950-9240

IS - 2

ER -