Genetic analysis of glioblastoma multiforme provides evidence for subgroups within the grade

Gayatry Mohapatra, Andrew W. Bollen, Dong H. Kim, Kathleen Lamborn, Dan H. Moore, Michael D. Prados, Burt G.F. Feuerstein

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Abstract

We analyzed 72 primary and 25 recurrent glioblastoma multiforme (GBM) samples for DNA sequence copy number abnormalities (CNAs) by comparative genomic hybridization (CGH). The number of aberrations per tumor ranged from 2 to 23 in primary GBM and 5 to 25 in recurrent GBM. There were 26 chromosome regions with CNAs in more than 20% of tumors. 7q22-36 was the most common gain and 10(q)25-26 was the most common loss; each occurred in more than 70% of tumors. Of 27 amplification sites, epidermal growth factor receptor (EGFR) was the most common; it was observed in 25% of primary GBMs. Statistical analysis based on pairwise correlation of CNAs indicated that there is more than one class of primary GBM.

Original languageEnglish (US)
Pages (from-to)195-206
Number of pages12
JournalGenes Chromosomes and Cancer
Volume21
Issue number3
DOIs
StatePublished - Mar 1998
Externally publishedYes

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Glioblastoma
Neoplasms
Comparative Genomic Hybridization
Epidermal Growth Factor Receptor
Chromosomes

ASJC Scopus subject areas

  • Cancer Research
  • Genetics

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Genetic analysis of glioblastoma multiforme provides evidence for subgroups within the grade. / Mohapatra, Gayatry; Bollen, Andrew W.; Kim, Dong H.; Lamborn, Kathleen; Moore, Dan H.; Prados, Michael D.; Feuerstein, Burt G.F.

In: Genes Chromosomes and Cancer, Vol. 21, No. 3, 03.1998, p. 195-206.

Research output: Contribution to journalArticle

Mohapatra, Gayatry ; Bollen, Andrew W. ; Kim, Dong H. ; Lamborn, Kathleen ; Moore, Dan H. ; Prados, Michael D. ; Feuerstein, Burt G.F. / Genetic analysis of glioblastoma multiforme provides evidence for subgroups within the grade. In: Genes Chromosomes and Cancer. 1998 ; Vol. 21, No. 3. pp. 195-206.
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