Genetic ancestry and the relationship of cigarette smoking to lung function and per cent emphysema in four race/ethnic groups: A cross-sectional study

Rhea Powell, Duncan Davidson, Jasmin Divers, Ani Manichaikul, J. Jeffrey Carr, Robert Detrano, Eric A. Hoffman, Rui Jiang, Richard A. Kronmal, Kiang Liu, Naresh M. Punjabi, Eyal Shahar, Karol E. Watson, Jerome I. Rotter, Kent D. Taylor, Stephen S. Rich, R. Graham Barr

Research output: Contribution to journalArticle

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Abstract

Background Cigarette smoking is the major cause of chronic obstructive pulmonary disease and emphysema. Recent studies suggest that susceptibility to cigarette smoke may vary by race/ethnicity; however, they were generally small and relied on self-reported race/ethnicity. Objective To test the hypothesis that relationships of smoking to lung function and per cent emphysema differ by genetic ancestry and self-reported race/ethnicity among Caucasians, African-Americans, Hispanics and Chinese-Americans. Design Cross-sectional population-based study of adults age 45-84 years in the USA. Measurements Principal components of genetic ancestry and continental ancestry estimated from one million genome-wide single nucleotide polymorphisms; pack-years of smoking; spirometry measured for 3344 participants; and per cent emphysema on computed tomography for 8224 participants. Results The prevalence of ever-smoking was: Caucasians, 57.6%; African-Americans, 56.4%; Hispanics, 46.7%; and Chinese-Americans, 26.8%. Every 10 pack-years was associated with -0.73% (95% CI -0.90% to -0.56%) decrement in the forced expiratory volume in 1 s to forced vital capacity (FEV1 to FVC) and a 0.23% (95% CI 0.08% to 0.38%) increase in per cent emphysema. There was no evidence that relationships of pack-years to the FEV1 to FVC, airflow obstruction and per cent emphysema varied by genetic ancestry (all p>0.10), self-reported race/ethnicity (all p>0.10) or, among African-Americans, African ancestry. There were small differences in relationships of packyears to the FEV1 among male Chinese-Americans and to the FEV1 to FVC ratio with African and Native American ancestry among male Hispanics only. Conclusions In this large cohort, there was little to no evidence that the associations of smoking to lung function and per cent emphysema differed by genetic ancestry or self-reported race/ethnicity.

Original languageEnglish (US)
Pages (from-to)634-642
Number of pages9
JournalThorax
Volume68
Issue number7
DOIs
StatePublished - Jul 2013

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Emphysema
Ethnic Groups
Cross-Sectional Studies
African Americans
Smoking
Asian Americans
Vital Capacity
Forced Expiratory Volume
Lung
Hispanic Americans
Pulmonary Emphysema
North American Indians
Spirometry
Smoke
Tobacco Products
Chronic Obstructive Pulmonary Disease
Single Nucleotide Polymorphism
Tomography
Genome
Population

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Genetic ancestry and the relationship of cigarette smoking to lung function and per cent emphysema in four race/ethnic groups : A cross-sectional study. / Powell, Rhea; Davidson, Duncan; Divers, Jasmin; Manichaikul, Ani; Carr, J. Jeffrey; Detrano, Robert; Hoffman, Eric A.; Jiang, Rui; Kronmal, Richard A.; Liu, Kiang; Punjabi, Naresh M.; Shahar, Eyal; Watson, Karol E.; Rotter, Jerome I.; Taylor, Kent D.; Rich, Stephen S.; Graham Barr, R.

In: Thorax, Vol. 68, No. 7, 07.2013, p. 634-642.

Research output: Contribution to journalArticle

Powell, R, Davidson, D, Divers, J, Manichaikul, A, Carr, JJ, Detrano, R, Hoffman, EA, Jiang, R, Kronmal, RA, Liu, K, Punjabi, NM, Shahar, E, Watson, KE, Rotter, JI, Taylor, KD, Rich, SS & Graham Barr, R 2013, 'Genetic ancestry and the relationship of cigarette smoking to lung function and per cent emphysema in four race/ethnic groups: A cross-sectional study', Thorax, vol. 68, no. 7, pp. 634-642. https://doi.org/10.1136/thoraxjnl-2012-202116
Powell, Rhea ; Davidson, Duncan ; Divers, Jasmin ; Manichaikul, Ani ; Carr, J. Jeffrey ; Detrano, Robert ; Hoffman, Eric A. ; Jiang, Rui ; Kronmal, Richard A. ; Liu, Kiang ; Punjabi, Naresh M. ; Shahar, Eyal ; Watson, Karol E. ; Rotter, Jerome I. ; Taylor, Kent D. ; Rich, Stephen S. ; Graham Barr, R. / Genetic ancestry and the relationship of cigarette smoking to lung function and per cent emphysema in four race/ethnic groups : A cross-sectional study. In: Thorax. 2013 ; Vol. 68, No. 7. pp. 634-642.
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abstract = "Background Cigarette smoking is the major cause of chronic obstructive pulmonary disease and emphysema. Recent studies suggest that susceptibility to cigarette smoke may vary by race/ethnicity; however, they were generally small and relied on self-reported race/ethnicity. Objective To test the hypothesis that relationships of smoking to lung function and per cent emphysema differ by genetic ancestry and self-reported race/ethnicity among Caucasians, African-Americans, Hispanics and Chinese-Americans. Design Cross-sectional population-based study of adults age 45-84 years in the USA. Measurements Principal components of genetic ancestry and continental ancestry estimated from one million genome-wide single nucleotide polymorphisms; pack-years of smoking; spirometry measured for 3344 participants; and per cent emphysema on computed tomography for 8224 participants. Results The prevalence of ever-smoking was: Caucasians, 57.6{\%}; African-Americans, 56.4{\%}; Hispanics, 46.7{\%}; and Chinese-Americans, 26.8{\%}. Every 10 pack-years was associated with -0.73{\%} (95{\%} CI -0.90{\%} to -0.56{\%}) decrement in the forced expiratory volume in 1 s to forced vital capacity (FEV1 to FVC) and a 0.23{\%} (95{\%} CI 0.08{\%} to 0.38{\%}) increase in per cent emphysema. There was no evidence that relationships of pack-years to the FEV1 to FVC, airflow obstruction and per cent emphysema varied by genetic ancestry (all p>0.10), self-reported race/ethnicity (all p>0.10) or, among African-Americans, African ancestry. There were small differences in relationships of packyears to the FEV1 among male Chinese-Americans and to the FEV1 to FVC ratio with African and Native American ancestry among male Hispanics only. Conclusions In this large cohort, there was little to no evidence that the associations of smoking to lung function and per cent emphysema differed by genetic ancestry or self-reported race/ethnicity.",
author = "Rhea Powell and Duncan Davidson and Jasmin Divers and Ani Manichaikul and Carr, {J. Jeffrey} and Robert Detrano and Hoffman, {Eric A.} and Rui Jiang and Kronmal, {Richard A.} and Kiang Liu and Punjabi, {Naresh M.} and Eyal Shahar and Watson, {Karol E.} and Rotter, {Jerome I.} and Taylor, {Kent D.} and Rich, {Stephen S.} and {Graham Barr}, R.",
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T1 - Genetic ancestry and the relationship of cigarette smoking to lung function and per cent emphysema in four race/ethnic groups

T2 - A cross-sectional study

AU - Powell, Rhea

AU - Davidson, Duncan

AU - Divers, Jasmin

AU - Manichaikul, Ani

AU - Carr, J. Jeffrey

AU - Detrano, Robert

AU - Hoffman, Eric A.

AU - Jiang, Rui

AU - Kronmal, Richard A.

AU - Liu, Kiang

AU - Punjabi, Naresh M.

AU - Shahar, Eyal

AU - Watson, Karol E.

AU - Rotter, Jerome I.

AU - Taylor, Kent D.

AU - Rich, Stephen S.

AU - Graham Barr, R.

PY - 2013/7

Y1 - 2013/7

N2 - Background Cigarette smoking is the major cause of chronic obstructive pulmonary disease and emphysema. Recent studies suggest that susceptibility to cigarette smoke may vary by race/ethnicity; however, they were generally small and relied on self-reported race/ethnicity. Objective To test the hypothesis that relationships of smoking to lung function and per cent emphysema differ by genetic ancestry and self-reported race/ethnicity among Caucasians, African-Americans, Hispanics and Chinese-Americans. Design Cross-sectional population-based study of adults age 45-84 years in the USA. Measurements Principal components of genetic ancestry and continental ancestry estimated from one million genome-wide single nucleotide polymorphisms; pack-years of smoking; spirometry measured for 3344 participants; and per cent emphysema on computed tomography for 8224 participants. Results The prevalence of ever-smoking was: Caucasians, 57.6%; African-Americans, 56.4%; Hispanics, 46.7%; and Chinese-Americans, 26.8%. Every 10 pack-years was associated with -0.73% (95% CI -0.90% to -0.56%) decrement in the forced expiratory volume in 1 s to forced vital capacity (FEV1 to FVC) and a 0.23% (95% CI 0.08% to 0.38%) increase in per cent emphysema. There was no evidence that relationships of pack-years to the FEV1 to FVC, airflow obstruction and per cent emphysema varied by genetic ancestry (all p>0.10), self-reported race/ethnicity (all p>0.10) or, among African-Americans, African ancestry. There were small differences in relationships of packyears to the FEV1 among male Chinese-Americans and to the FEV1 to FVC ratio with African and Native American ancestry among male Hispanics only. Conclusions In this large cohort, there was little to no evidence that the associations of smoking to lung function and per cent emphysema differed by genetic ancestry or self-reported race/ethnicity.

AB - Background Cigarette smoking is the major cause of chronic obstructive pulmonary disease and emphysema. Recent studies suggest that susceptibility to cigarette smoke may vary by race/ethnicity; however, they were generally small and relied on self-reported race/ethnicity. Objective To test the hypothesis that relationships of smoking to lung function and per cent emphysema differ by genetic ancestry and self-reported race/ethnicity among Caucasians, African-Americans, Hispanics and Chinese-Americans. Design Cross-sectional population-based study of adults age 45-84 years in the USA. Measurements Principal components of genetic ancestry and continental ancestry estimated from one million genome-wide single nucleotide polymorphisms; pack-years of smoking; spirometry measured for 3344 participants; and per cent emphysema on computed tomography for 8224 participants. Results The prevalence of ever-smoking was: Caucasians, 57.6%; African-Americans, 56.4%; Hispanics, 46.7%; and Chinese-Americans, 26.8%. Every 10 pack-years was associated with -0.73% (95% CI -0.90% to -0.56%) decrement in the forced expiratory volume in 1 s to forced vital capacity (FEV1 to FVC) and a 0.23% (95% CI 0.08% to 0.38%) increase in per cent emphysema. There was no evidence that relationships of pack-years to the FEV1 to FVC, airflow obstruction and per cent emphysema varied by genetic ancestry (all p>0.10), self-reported race/ethnicity (all p>0.10) or, among African-Americans, African ancestry. There were small differences in relationships of packyears to the FEV1 among male Chinese-Americans and to the FEV1 to FVC ratio with African and Native American ancestry among male Hispanics only. Conclusions In this large cohort, there was little to no evidence that the associations of smoking to lung function and per cent emphysema differed by genetic ancestry or self-reported race/ethnicity.

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