Genetic and Epigenetics of Type 2 Diabetes

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Over the past three decades, the global prevalence of type 2 diabetes (T2D) has rapidly and relentlessly increased, and in the United States, 8.3% have T2D. In order to prevent the epidemic rise, it is necessary to define the genetic and epigenetic defects responsible for characterizing this common and complex disease. T2D is characterized by chronic hyperglycemia and arises from a combination of insuLin resistance and beta-cell dysfunction. Environmental factors including physical inactivity and caloric excess play a key role in the development of the disease. However, genetic factors also contribute to the pathogenesis of T2D, and more recently, epigenetic influences such as DNA methylation, histone modifications, and microRNAs have been proposed in the pathogenesis of this complex disease. This article will provide an up-to-date review on the genetics and epigenetics of T2D.

Original languageEnglish (US)
Title of host publicationPathobiology of Human Disease
Subtitle of host publicationA Dynamic Encyclopedia of Disease Mechanisms
PublisherElsevier Inc.
Pages467-476
Number of pages10
ISBN (Electronic)9780123864567
ISBN (Print)9780123864574
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

Keywords

  • Candidate gene association studies
  • DNA methylation
  • Epigenetics
  • Genetics
  • Genome-wide association studies
  • Genome-wide Linkage mapping
  • GWAS
  • HeritabiLity
  • Histone modifications
  • Human genome
  • Meta-analysis
  • MicroRNAs
  • Next-generation sequencing
  • Rare variation
  • Type 2 diabetes

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Coletta, D. K. (2014). Genetic and Epigenetics of Type 2 Diabetes. In Pathobiology of Human Disease: A Dynamic Encyclopedia of Disease Mechanisms (pp. 467-476). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-386456-7.02002-5