Genetic and molecular mechanisms of chemical atherogenesis

Kenneth S. Ramos, Charles R. Partridge, Ivo Teneng

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Injury to the cellular components of the vascular wall and blood by endogenous and exogenous chemicals has been associated with atherosclerosis in humans and experimental systems. The genetic and molecular mechanisms responsible for initiation and promotion of atherosclerotic changes include modulation of extracellular matrix-integrin axis, genes involved in the regulation of growth and differentiation and possibly, genomic stability. This review summarizes seminal studies over the past 20 years that shed light on critical gene-gene and gene-environment interactions mediating the atherogenic response to chemical injury.

Original languageEnglish (US)
Pages (from-to)18-30
Number of pages13
JournalMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume621
Issue number1-2
DOIs
StatePublished - Aug 1 2007
Externally publishedYes

Keywords

  • Atherosclerosis
  • Chemical injury
  • Genetics
  • LINE-1
  • Osteopontin

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Health, Toxicology and Mutagenesis

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