Genetic polymorphism in allergy and asthma

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

The impact of genetic factors on the pathogenesis of allergy and asthma is currently an area of intense investigation. Although epidemiological studies find more and more genes that are likely to contribute to allergic inflammation, functional studies of the mechanisms that link genetic variation with dysregulation of gene expression and function are hindered by the high frequency of natural variation. The interplay between genes and environment adds another layer of complexity to the determination of allergic phenotypes. The complexity emerging from these studies warrants novel experimental strategies and bolder conceptual paradigms.

Original languageEnglish (US)
Pages (from-to)609-613
Number of pages5
JournalCurrent Opinion in Immunology
Volume15
Issue number6
DOIs
StatePublished - Dec 2003

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Genetic Polymorphisms
Hypersensitivity
Asthma
Genes
Epidemiologic Studies
Inflammation
Phenotype
Gene Expression

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Genetic polymorphism in allergy and asthma. / Vercelli, Donata.

In: Current Opinion in Immunology, Vol. 15, No. 6, 12.2003, p. 609-613.

Research output: Contribution to journalArticle

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