Genetic structure among 38 populations from the United States based on 11 U.S. core Y chromosome STRs

Alan J. Redd, Veronica F. Chamberlain, Veronica F. Kearney, Daryn Stover, Tatiana Karafet, Karl Calderon, James "Bruce" Walsh, Michael F Hammer

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

A DNA database consisting of the 11 Y chromosome short-tandem-repeat (Y-STR) recommended by the Scientific Working Group on DNA Analysis Methods is constructed for 2517 individuals from 38 populations in the United States. The population samples derive from five ethnic groups currently living in 10 states. A multidimensional scaling (MDS) plot places the populations into four discrete clusters (African Americans (AA), European Americans (EA), Hispanic Americans (HA), and Asian Americans (SA)) and one dispersed cluster of Native Americans. An analysis of molecular variance (AMOVA) indicates that a large proportion of the total genetic variance is partitioned among ethnic groups (24.8%), whereas only a small amount (1.5%) is found among-populations within ethnic groups. Separate AMOVA analyses within each ethnic group show that only the NA sample contains statistically significant among-population variation. Pair wise population differentiation tests do uncover heterogeneity among EA and among HA populations; however, this is due to only a single sample within each group. The analyses support the creation of AA, EA, HA, and Asian American databases in which samples from different geographic regions within the United States are pooled. We recommend that separate databases be constructed for different NA groups.

Original languageEnglish (US)
Pages (from-to)580-585
Number of pages6
JournalJournal of Forensic Sciences
Volume51
Issue number3
DOIs
StatePublished - May 2006

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Genetic Structures
Y Chromosome
Ethnic Groups
ethnic group
Population
Hispanic Americans
Analysis of Variance
Asian Americans
analysis of variance
African Americans
Databases
genetic test
North American Indians
multidimensional scaling
Nucleic Acid Databases
working group
Microsatellite Repeats
Group
DNA

Keywords

  • African American
  • Asian American
  • DYS19
  • DYS385ab
  • DYS389I
  • DYS389II
  • DYS390
  • DYS391
  • DYS392
  • DYS393
  • DYS438
  • DYS439
  • European American
  • Forensic science
  • Hispanic American
  • Native American
  • Population structure
  • Short tandem repeats
  • Y chromosome DNA

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Law

Cite this

Genetic structure among 38 populations from the United States based on 11 U.S. core Y chromosome STRs. / Redd, Alan J.; Chamberlain, Veronica F.; Kearney, Veronica F.; Stover, Daryn; Karafet, Tatiana; Calderon, Karl; Walsh, James "Bruce"; Hammer, Michael F.

In: Journal of Forensic Sciences, Vol. 51, No. 3, 05.2006, p. 580-585.

Research output: Contribution to journalArticle

Redd, Alan J. ; Chamberlain, Veronica F. ; Kearney, Veronica F. ; Stover, Daryn ; Karafet, Tatiana ; Calderon, Karl ; Walsh, James "Bruce" ; Hammer, Michael F. / Genetic structure among 38 populations from the United States based on 11 U.S. core Y chromosome STRs. In: Journal of Forensic Sciences. 2006 ; Vol. 51, No. 3. pp. 580-585.
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