Genioglossus and hyoglossus muscle activation during sustained asphyxia in rats

P. L. Janssen, J. S. Williams, Ralph F Fregosi

Research output: Contribution to journalArticle

Abstract

Episodes of apnea caused by pharyngeal airway obstruction produce sustained asphyxia in sleep apnea patients, but little is known of the effects of prolonged asphyxia on muscles which are involved in the control of upper airway caliber. We therefore examined the responses of retractor and protrudor muscles of the tongue (hyoglossus (HG) and genioglossus (GG) muscles, respectively) during sustained asphyxia in anesthetized and vagotomized spontaneously breathing rats (250-300 g). EMG activities of GG and HG muscles were recorded during exposure to 6 min of asphyxia (F1O2 = 0.15; F1CO2 = 0.07; n=7), and additionally during 6 min of hypoxia (F1O2 = 015; n=5). The magnitude and direction of tongue movement was also determined by connecting a suture from a force transducer to the tip of the rat's tongue. EMG activities of both muscles were increased from baseline levels after 30 sec of asphyxia [+48.2 ± 44 % (GG) and +42.4 ± 4.3 % (HG); mean ± SE], and remained elevated after 6 min of asphyxia [+45.6 ± 8.4%(GG); +51.0 ± 7.6%(HG)]. Sustained hypoxia produced a biphasic response for both muscles (stimulation followed by roll-off). Both asphyxia and hypoxia elicited a net retractive movement of the tongue. The time-course of the tongue movement responses mimiced the EMG responses. These results indicate that: 1) retractor and protrudor muscles of the tongue are co-activated during sustained asphyxia and hypoxia in rats; 2) co-activation is associated with tongue retraction; and 3) the GG and HG behave similar to other respiratory muscles during conditions of respiratory stress in rats.

Original languageEnglish (US)
JournalFASEB Journal
Volume12
Issue number5
StatePublished - Mar 20 1998

Fingerprint

asphyxia
Asphyxia
tongue
Muscle
Rats
Tongue
Chemical activation
Muscles
muscles
rats
hypoxia
sleep apnea
apnea
Respiratory Muscles
Airway Management
transducers (equipment)
intestinal obstruction
Sleep Apnea Syndromes
Apnea
Airway Obstruction

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Genioglossus and hyoglossus muscle activation during sustained asphyxia in rats. / Janssen, P. L.; Williams, J. S.; Fregosi, Ralph F.

In: FASEB Journal, Vol. 12, No. 5, 20.03.1998.

Research output: Contribution to journalArticle

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