Genome Duplication, Subfunction Partitioning, and Lineage Divergence: Sox9 in Stickleback and Zebrafish

William A. Cresko, Yi Lin Yan, David A. Baltrus, Angel Amores, Amy Singer, Adriana Rodríguez-Marí, John H. Postlethwait

Research output: Contribution to journalReview articlepeer-review

96 Scopus citations

Abstract

Teleosts are the most species-rich group of vertebrates, and a genome duplication (tetraploidization) event in ray-fin fish appears to have preceded this remarkable explosion of biodiversity. What is the relationship of the ray-fin genome duplication to the teleost radiation? Genome duplication may have facilitated lineage divergence by partitioning different ancestral gene subfunctions among co-orthologs of tetrapod genes in different teleost lineages. To test this hypothesis, we investigated gene expression patterns for Sox9 gene duplicates in stickleback and zebrafish, teleosts whose lineages diverged early in Euteleost evolution. Most expression domains appear to have been partitioned between Sox9a and Sox9b before the divergence of stickleback and zebrafish lineages, but some ancestral expression domains were distributed differentially in each lineage. We conclude that some gene subfunctions, as represented by lineage-specific expression domains, may have assorted differently in separate lineages and that these may have contributed to lineage diversification during teleost evolution.

Original languageEnglish (US)
Pages (from-to)480-489
Number of pages10
JournalDevelopmental Dynamics
Volume228
Issue number3
DOIs
StatePublished - Nov 2003

Keywords

  • Chondrogenesis
  • Genome duplication
  • Macroevolution
  • Sex determination
  • Subfunctionalization
  • Tetraploidization
  • Transcription factor

ASJC Scopus subject areas

  • Developmental Biology

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