Genome sequence of the progenitor of the wheat D genome Aegilops tauschii

Ming Cheng Luo, Yong Q. Gu, Daniela Puiu, Hao Wang, Sven O. Twardziok, Karin R. Deal, Naxin Huo, Tingting Zhu, Le Wang, Yi Wang, Patrick E. McGuire, Shuyang Liu, Hai Long, Ramesh K. Ramasamy, Juan C. Rodriguez, L. Van Sonny, Luxia Yuan, Zhenzhong Wang, Zhiqiang Xia, Lichan XiaoOlin D. Anderson, Shuhong Ouyang, Yong Liang, Aleksey V. Zimin, Geo Pertea, Peng Qi, Jeffrey L. Bennetzen, Xiongtao Dai, Matthew W. Dawson, Hans Georg Müller, Karl Kugler, Lorena Rivarola-Duarte, Manuel Spannagl, Klaus F.X. Mayer, Fu Hao Lu, Michael W. Bevan, Philippe Leroy, Pingchuan Li, Frank M. You, Qixin Sun, Zhiyong Liu, Eric H Lyons, Thomas Wicker, Steven L. Salzberg, Katrien M. Devos, Jan Dvoák

Research output: Contribution to journalArticle

158 Scopus citations

Abstract

Aegilops tauschii is the diploid progenitor of the D genome of hexaploid wheat (Triticum aestivum, genomes AABBDD) and an important genetic resource for wheat. The large size and highly repetitive nature of the Ae. tauschii genome has until now precluded the development of a reference-quality genome sequence. Here we use an array of advanced technologies, including ordered-clone genome sequencing, whole-genome shotgun sequencing, and BioNano optical genome mapping, to generate a reference-quality genome sequence for Ae. tauschii ssp. strangulata accession AL8/78, which is closely related to the wheat D genome. We show that compared to other sequenced plant genomes, including a much larger conifer genome, the Ae. tauschii genome contains unprecedented amounts of very similar repeated sequences. Our genome comparisons reveal that the Ae. tauschii genome has a greater number of dispersed duplicated genes than other sequenced genomes and its chromosomes have been structurally evolving an order of magnitude faster than those of other grass genomes. The decay of colinearity with other grass genomes correlates with recombination rates along chromosomes. We propose that the vast amounts of very similar repeated sequences cause frequent errors in recombination and lead to gene duplications and structural chromosome changes that drive fast genome evolution.

Original languageEnglish (US)
Pages (from-to)498-502
Number of pages5
JournalNature
Volume551
Issue number7681
DOIs
StatePublished - Nov 23 2017

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    Luo, M. C., Gu, Y. Q., Puiu, D., Wang, H., Twardziok, S. O., Deal, K. R., Huo, N., Zhu, T., Wang, L., Wang, Y., McGuire, P. E., Liu, S., Long, H., Ramasamy, R. K., Rodriguez, J. C., Van Sonny, L., Yuan, L., Wang, Z., Xia, Z., ... Dvoák, J. (2017). Genome sequence of the progenitor of the wheat D genome Aegilops tauschii. Nature, 551(7681), 498-502. https://doi.org/10.1038/nature24486