Abstract
Tsetse flies are the sole vectors of human African trypanosomiasis throughout sub-Saharan Africa. Both sexes of adult tsetse feed exclusively on blood and contribute to disease transmission. Notable differences between tsetse and other disease vectors include obligate microbial symbioses, viviparous reproduction, and lactation. Here, we describe the sequence and annotation of the 366-megabase Glossina morsitans morsitans genome. Analysis of the genome and the 12,308 predicted protein-encoding genes led to multiple discoveries, including chromosomal integrations of bacterial (Wolbachia) genome sequences, a family of lactation-specific proteins, reduced complement of host pathogen recognition proteins, and reduced olfaction/chemosensory associated genes. These genome data provide a foundation for research into trypanosomiasis prevention and yield important insights with broad implications for multiple aspects of tsetse biology.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 380-386 |
| Number of pages | 7 |
| Journal | Science |
| Volume | 344 |
| Issue number | 6182 |
| DOIs | |
| State | Published - 2014 |
ASJC Scopus subject areas
- General
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Genome sequence of the tsetse fly (Glossina morsitans ) : Vector of African trypanosomiasis. / Watanabe, Junichi; Hattori, Masahira; Berriman, Matthew; Lehane, Michael J.; Hall, Neil; Solano, Philippe; Aksoy, Serap; Hide, Winston; Touré, Yeya; Attardo, Geoffrey M.; Darby, Alistair C.; Toyoda, Atsushi; Hertz-Fowler, Christiane; Larkin, Denis M.; Cotton, James A.; Sanders, Mandy J.; Swain, Martin T.; Quail, Michael A.; Inoue, Noboru; Ravel, Sophie; Taylor, Todd D.; Srivastava, Tulika P.; Sharma, Vineet; Warren, Wesley; Wilson, Richard K.; Suzuki, Yutaka; Lawson, Daniel; Hughes, Daniel S.T.; Megy, Karyn; Masiga, Daniel K.; Mireji, Paul O.; Hansen, Immo A.; Van Den Abbeele, Jan; Benoit, Joshua B.; Bourtzis, Kostas; Obiero, George F.O.; Robertson, Hugh M.; Jones, Jeffery W.; Zhou, Jing Jiang; Field, Linda M.; Friedrich, Markus; Nyanjom, Steven R.G.; Telleria, Erich L.; Caljon, Guy; Ribeiro, José M.C.; Acosta-Serrano, Alvaro; Ooi, Cher Pheng; Rose, Clair; Price, David P.; Haines, Lee R.; Christoffels, Alan; Sim, Cheolho; Pham, Daphne Q.D.; Denlinger, David L.; Geiser, Dawn L.; Omedo, Irene A.; Winzerling, Joy J.; Peyton, Justin T.; Marucha, Kevin K.; Jonas, Mario; Meuti, Megan E.; Rawlings, Neil D.; Zhang, Qirui; Macharia, Rosaline W.; Michalkova, Veronika; Dashti, Zahra Jalali Sefid; Baumann, Aaron A.; Gäde, Gerd; Marco, Heather G.; Caers, Jelle; Schoofs, Liliane; Riehle, Michael A.; Hu, Wanqi; Tu, Zhijian; Tarone, Aaron M.; Malacrida, Anna R.; Kibet, Caleb K.; Scolari, Francesca; Koekemoer, Jacobus J.O.; Willis, Judith; Gomulski, Ludvik M.; Falchetto, Marco; Scott, Maxwell J.; Fu, Shuhua; Sze, Sing Hoi; Luiz, Thiago; Weiss, Brian; Walshe, Deirdre P.; Wang, Jingwen; Wamalwa, Mark; Mwangi, Sarah; Ramphul, Urvashi N.; Snyder, Anna K.; Brelsfoard, Corey L.; Thomas, Gavin H.; Tsiamis, George; Arensburger, Peter; Rio, Rita V.M.; Macdonald, Sandy J.; Panji, Sumir; Kruger, Adele; Benkahla, Alia; Balyeidhusa, Apollo S.P.; Msangi, Atway; Okoro, Chinyere K.; Stephens, Dawn; Stanley, Eleanor J.; Mpondo, Feziwe; Wamwiri, Florence; Mramba, Furaha; Siwo, Geoffrey; Githinji, George; Harkins, Gordon; Murilla, Grace; Lehväslaiho, Heikki; Malele, Imna; Auma, Joanna E.; Kinyua, Johnson K.; Ouma, Johnson; Okedi, Loyce; Manga, Lucien; Aslett, Martin; Koffi, Mathurin; Gaunt, Michael W.; Makgamathe, Mmule; Mulder, Nicola; Manangwa, Oliver; Abila, Patrick P.; Wincker, Patrick; Gregory, Richard; Bateta, Rosemary; Sakate, Ryuichi; Ommeh, Sheila; Lehane, Stella; Imanishi, Tadashi; Osamor, Victor C.; Kawahara, Yoshihiro.
In: Science, Vol. 344, No. 6182, 2014, p. 380-386.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Genome sequence of the tsetse fly (Glossina morsitans )
T2 - Vector of African trypanosomiasis
AU - Watanabe, Junichi
AU - Hattori, Masahira
AU - Berriman, Matthew
AU - Lehane, Michael J.
AU - Hall, Neil
AU - Solano, Philippe
AU - Aksoy, Serap
AU - Hide, Winston
AU - Touré, Yeya
AU - Attardo, Geoffrey M.
AU - Darby, Alistair C.
AU - Toyoda, Atsushi
AU - Hertz-Fowler, Christiane
AU - Larkin, Denis M.
AU - Cotton, James A.
AU - Sanders, Mandy J.
AU - Swain, Martin T.
AU - Quail, Michael A.
AU - Inoue, Noboru
AU - Ravel, Sophie
AU - Taylor, Todd D.
AU - Srivastava, Tulika P.
AU - Sharma, Vineet
AU - Warren, Wesley
AU - Wilson, Richard K.
AU - Suzuki, Yutaka
AU - Lawson, Daniel
AU - Hughes, Daniel S.T.
AU - Megy, Karyn
AU - Masiga, Daniel K.
AU - Mireji, Paul O.
AU - Hansen, Immo A.
AU - Van Den Abbeele, Jan
AU - Benoit, Joshua B.
AU - Bourtzis, Kostas
AU - Obiero, George F.O.
AU - Robertson, Hugh M.
AU - Jones, Jeffery W.
AU - Zhou, Jing Jiang
AU - Field, Linda M.
AU - Friedrich, Markus
AU - Nyanjom, Steven R.G.
AU - Telleria, Erich L.
AU - Caljon, Guy
AU - Ribeiro, José M.C.
AU - Acosta-Serrano, Alvaro
AU - Ooi, Cher Pheng
AU - Rose, Clair
AU - Price, David P.
AU - Haines, Lee R.
AU - Christoffels, Alan
AU - Sim, Cheolho
AU - Pham, Daphne Q.D.
AU - Denlinger, David L.
AU - Geiser, Dawn L.
AU - Omedo, Irene A.
AU - Winzerling, Joy J.
AU - Peyton, Justin T.
AU - Marucha, Kevin K.
AU - Jonas, Mario
AU - Meuti, Megan E.
AU - Rawlings, Neil D.
AU - Zhang, Qirui
AU - Macharia, Rosaline W.
AU - Michalkova, Veronika
AU - Dashti, Zahra Jalali Sefid
AU - Baumann, Aaron A.
AU - Gäde, Gerd
AU - Marco, Heather G.
AU - Caers, Jelle
AU - Schoofs, Liliane
AU - Riehle, Michael A.
AU - Hu, Wanqi
AU - Tu, Zhijian
AU - Tarone, Aaron M.
AU - Malacrida, Anna R.
AU - Kibet, Caleb K.
AU - Scolari, Francesca
AU - Koekemoer, Jacobus J.O.
AU - Willis, Judith
AU - Gomulski, Ludvik M.
AU - Falchetto, Marco
AU - Scott, Maxwell J.
AU - Fu, Shuhua
AU - Sze, Sing Hoi
AU - Luiz, Thiago
AU - Weiss, Brian
AU - Walshe, Deirdre P.
AU - Wang, Jingwen
AU - Wamalwa, Mark
AU - Mwangi, Sarah
AU - Ramphul, Urvashi N.
AU - Snyder, Anna K.
AU - Brelsfoard, Corey L.
AU - Thomas, Gavin H.
AU - Tsiamis, George
AU - Arensburger, Peter
AU - Rio, Rita V.M.
AU - Macdonald, Sandy J.
AU - Panji, Sumir
AU - Kruger, Adele
AU - Benkahla, Alia
AU - Balyeidhusa, Apollo S.P.
AU - Msangi, Atway
AU - Okoro, Chinyere K.
AU - Stephens, Dawn
AU - Stanley, Eleanor J.
AU - Mpondo, Feziwe
AU - Wamwiri, Florence
AU - Mramba, Furaha
AU - Siwo, Geoffrey
AU - Githinji, George
AU - Harkins, Gordon
AU - Murilla, Grace
AU - Lehväslaiho, Heikki
AU - Malele, Imna
AU - Auma, Joanna E.
AU - Kinyua, Johnson K.
AU - Ouma, Johnson
AU - Okedi, Loyce
AU - Manga, Lucien
AU - Aslett, Martin
AU - Koffi, Mathurin
AU - Gaunt, Michael W.
AU - Makgamathe, Mmule
AU - Mulder, Nicola
AU - Manangwa, Oliver
AU - Abila, Patrick P.
AU - Wincker, Patrick
AU - Gregory, Richard
AU - Bateta, Rosemary
AU - Sakate, Ryuichi
AU - Ommeh, Sheila
AU - Lehane, Stella
AU - Imanishi, Tadashi
AU - Osamor, Victor C.
AU - Kawahara, Yoshihiro
PY - 2014
Y1 - 2014
N2 - Tsetse flies are the sole vectors of human African trypanosomiasis throughout sub-Saharan Africa. Both sexes of adult tsetse feed exclusively on blood and contribute to disease transmission. Notable differences between tsetse and other disease vectors include obligate microbial symbioses, viviparous reproduction, and lactation. Here, we describe the sequence and annotation of the 366-megabase Glossina morsitans morsitans genome. Analysis of the genome and the 12,308 predicted protein-encoding genes led to multiple discoveries, including chromosomal integrations of bacterial (Wolbachia) genome sequences, a family of lactation-specific proteins, reduced complement of host pathogen recognition proteins, and reduced olfaction/chemosensory associated genes. These genome data provide a foundation for research into trypanosomiasis prevention and yield important insights with broad implications for multiple aspects of tsetse biology.
AB - Tsetse flies are the sole vectors of human African trypanosomiasis throughout sub-Saharan Africa. Both sexes of adult tsetse feed exclusively on blood and contribute to disease transmission. Notable differences between tsetse and other disease vectors include obligate microbial symbioses, viviparous reproduction, and lactation. Here, we describe the sequence and annotation of the 366-megabase Glossina morsitans morsitans genome. Analysis of the genome and the 12,308 predicted protein-encoding genes led to multiple discoveries, including chromosomal integrations of bacterial (Wolbachia) genome sequences, a family of lactation-specific proteins, reduced complement of host pathogen recognition proteins, and reduced olfaction/chemosensory associated genes. These genome data provide a foundation for research into trypanosomiasis prevention and yield important insights with broad implications for multiple aspects of tsetse biology.
UR - http://www.scopus.com/inward/record.url?scp=84899560044&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84899560044&partnerID=8YFLogxK
U2 - 10.1126/science.1249656
DO - 10.1126/science.1249656
M3 - Article
C2 - 24763584
AN - SCOPUS:84899560044
VL - 344
SP - 380
EP - 386
JO - Science
JF - Science
SN - 0036-8075
IS - 6182
ER -