Genome sequencing reveals widespread virulence gene exchange among human Neisseria species

Pradeep Reddy Marri, Mary Paniscus, Nathan J. Weyand, María A. Rendón, Christine M. Calton, Diana R. Hernández, Dustin L. Higashi, Erica Sodergren, George M. Weinstock, Steven D. Rounsley, Magdalene "Maggie" So

Research output: Contribution to journalArticle

106 Citations (Scopus)

Abstract

Commensal bacteria comprise a large part of the microbial world, playing important roles in human development, health and disease. However, little is known about the genomic content of commensals or how related they are to their pathogenic counterparts. The genus Neisseria, containing both commensal and pathogenic species, provides an excellent opportunity to study these issues. We undertook a comprehensive sequencing and analysis of human commensal and pathogenic Neisseria genomes. Commensals have an extensive repertoire of virulence alleles, a large fraction of which has been exchanged among Neisseria species. Commensals also have the genetic capacity to donate DNA to, and take up DNA from, other Neisseria. Our findings strongly suggest that commensal Neisseria serve as reservoirs of virulence alleles, and that they engage extensively in genetic exchange.

Original languageEnglish (US)
Article numbere11835
JournalPLoS One
Volume5
Issue number7
DOIs
StatePublished - 2010

Fingerprint

Neisseria
Virulence
virulence
Genes
Genome
genome
DNA
Bacteria
genes
Health
Alleles
alleles
human development
Human Development
genomics
bacteria

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Marri, P. R., Paniscus, M., Weyand, N. J., Rendón, M. A., Calton, C. M., Hernández, D. R., ... So, M. M. (2010). Genome sequencing reveals widespread virulence gene exchange among human Neisseria species. PLoS One, 5(7), [e11835]. https://doi.org/10.1371/journal.pone.0011835

Genome sequencing reveals widespread virulence gene exchange among human Neisseria species. / Marri, Pradeep Reddy; Paniscus, Mary; Weyand, Nathan J.; Rendón, María A.; Calton, Christine M.; Hernández, Diana R.; Higashi, Dustin L.; Sodergren, Erica; Weinstock, George M.; Rounsley, Steven D.; So, Magdalene "Maggie".

In: PLoS One, Vol. 5, No. 7, e11835, 2010.

Research output: Contribution to journalArticle

Marri, PR, Paniscus, M, Weyand, NJ, Rendón, MA, Calton, CM, Hernández, DR, Higashi, DL, Sodergren, E, Weinstock, GM, Rounsley, SD & So, MM 2010, 'Genome sequencing reveals widespread virulence gene exchange among human Neisseria species', PLoS One, vol. 5, no. 7, e11835. https://doi.org/10.1371/journal.pone.0011835
Marri PR, Paniscus M, Weyand NJ, Rendón MA, Calton CM, Hernández DR et al. Genome sequencing reveals widespread virulence gene exchange among human Neisseria species. PLoS One. 2010;5(7). e11835. https://doi.org/10.1371/journal.pone.0011835
Marri, Pradeep Reddy ; Paniscus, Mary ; Weyand, Nathan J. ; Rendón, María A. ; Calton, Christine M. ; Hernández, Diana R. ; Higashi, Dustin L. ; Sodergren, Erica ; Weinstock, George M. ; Rounsley, Steven D. ; So, Magdalene "Maggie". / Genome sequencing reveals widespread virulence gene exchange among human Neisseria species. In: PLoS One. 2010 ; Vol. 5, No. 7.
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