Genome sequencing reveals widespread virulence gene exchange among human Neisseria species

Pradeep Reddy Marri, Mary Paniscus, Nathan J. Weyand, María A. Rendón, Christine M. Calton, Diana R. Hernández, Dustin L. Higashi, Erica Sodergren, George M. Weinstock, Steven D. Rounsley, Magdalene So

Research output: Contribution to journalArticle

115 Scopus citations

Abstract

Commensal bacteria comprise a large part of the microbial world, playing important roles in human development, health and disease. However, little is known about the genomic content of commensals or how related they are to their pathogenic counterparts. The genus Neisseria, containing both commensal and pathogenic species, provides an excellent opportunity to study these issues. We undertook a comprehensive sequencing and analysis of human commensal and pathogenic Neisseria genomes. Commensals have an extensive repertoire of virulence alleles, a large fraction of which has been exchanged among Neisseria species. Commensals also have the genetic capacity to donate DNA to, and take up DNA from, other Neisseria. Our findings strongly suggest that commensal Neisseria serve as reservoirs of virulence alleles, and that they engage extensively in genetic exchange.

Original languageEnglish (US)
Article numbere11835
JournalPloS one
Volume5
Issue number7
DOIs
StatePublished - 2010

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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    Marri, P. R., Paniscus, M., Weyand, N. J., Rendón, M. A., Calton, C. M., Hernández, D. R., Higashi, D. L., Sodergren, E., Weinstock, G. M., Rounsley, S. D., & So, M. (2010). Genome sequencing reveals widespread virulence gene exchange among human Neisseria species. PloS one, 5(7), [e11835]. https://doi.org/10.1371/journal.pone.0011835