Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21

Christopher A. Haiman, Gary K. Chen, William J. Blot, Sara S. Strom, Sonja I. Berndt, Rick A. Kittles, Benjamin A. Rybicki, William B. Isaacs, Sue A. Ingles, Janet L. Stanford, W. Ryan Diver, John S. Witte, Ann W. Hsing, Barbara Nemesure, Timothy R. Rebbeck, Kathleen A. Cooney, Jianfeng Xu, Adam S. Kibel, Jennifer J. Hu, Esther M. JohnSerigne M. Gueye, Stephen Watya, Lisa B. Signorello, Richard B. Hayes, Zhaoming Wang, Edward Yeboah, Yao Tettey, Qiuyin Cai, Suzanne Kolb, Elaine A. Ostrander, Charnita Zeigler-Johnson, Yuko Yamamura, Christine Neslund-Dudas, Jennifer Haslag-Minoff, William Wu, Venetta Thomas, Glenn O. Allen, Adam Murphy, Bao Li Chang, S. Lilly Zheng, M. Cristina Leske, Suh Yuh Wu, Anna M. Ray, Anselm J.M. Hennis, Michael J. Thun, John Carpten, Graham Casey, Erin N. Carter, Edder R. Duarte, Lucy Y. Xia, Xin Sheng, Peggy Wan, Loreall C. Pooler, Iona Cheng, Kristine R. Monroe, Fredrick Schumacher, Loic Le Marchand, Laurence N. Kolonel, Stephen J. Chanock, David Van Den Berg, Daniel O. Stram, Brian E. Henderson

Research output: Contribution to journalArticlepeer-review

153 Scopus citations

Abstract

In search of common risk alleles for prostate cancer that could contribute to high rates of the disease in men of African ancestry, we conducted a genome-wide association study, with 1,047,986 SNP markers examined in 3,425 African-Americans with prostate cancer (cases) and 3,290 African-American male controls. We followed up the most significant 17 new associations from stage 1 in 1,844 cases and 3,269 controls of African ancestry. We identified a new risk variant on chromosome 17q21 (rs7210100, odds ratio per allele = 1.51, P = 3.4 × 10-13). The frequency of the risk allele is ̃5% in men of African descent, whereas it is rare in other populations (<1%). Further studies are needed to investigate the biological contribution of this allele to prostate cancer risk. These findings emphasize the importance of conducting genome-wide association studies in diverse populations.

Original languageEnglish (US)
Pages (from-to)570-573
Number of pages4
JournalNature Genetics
Volume43
Issue number6
DOIs
StatePublished - Jun 2011

ASJC Scopus subject areas

  • Genetics

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