Genome-wide linkage of 77 families from the African American Hereditary Prostate Cancer Study (AAHPC)

Agnes B. Baffoe-Bonnie, Rick A. Kittles, Elizabeth Gillanders, Liang Ou, Asha George, Christiane Robbins, Chiledum Ahaghotu, James Bennett, William Boykin, Gerald Hoke, Terry Mason, Curtis Pettaway, Srinivasan Vijayakumar, Sally Weinrich, Mary P. Jones, Derek Gildea, Erica Riedesel, Julie Albertus, Tracy Moses, Erica LockwoodMeghan Klaric, Mezbah Faruque, Charmaine Royal, Jeffrey M. Trent, Kate Berg, Francis S. Collins, Paulette M. Furbert-Harris, Joan E. Bailey-Wilson, Georgia M. Dunston, Isaac Powell, John D. Carpten

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

BACKGROUND. The African American Hereditary Prostate Cancer (AAHPC) Study was designed to recruit families with early-onset disease fulfilling criteria of ≥4 affected. METHODS. We present a ∼10 cM genome-wide linkage (GWL) analysis on 77 families including 254 affected and 274 unaffected genotyped. RESULTS. Linkage analysis revealed three chromosomal regions with GENEHUNTER multipoint HLOD scores ≥1.3 for all 77 families at 11q22, 17p11, and Xq21. One family yielded genome-wide significant evidence of linkage (LOD = 3.5) to the 17p11 region with seven other families ≥2.3 in this region. Twenty-nine families with no-male-to-male (MM) transmission gave a peak HLOD of 1.62 (α = 0.33) at the Xq21 locus. Two novel peaks ≥0.91 for the 16 families with '>6 affected' occurred at 2p21 and 22q12. CONCLUSIONS. These chromosomal regions in the genome warrant further follow-up based on the hypothesis of multiple susceptibility genes with modest effects, or several major genes segregating in small subsets of families.

Original languageEnglish (US)
Pages (from-to)22-31
Number of pages10
JournalProstate
Volume67
Issue number1
DOIs
StatePublished - Jan 1 2007
Externally publishedYes

Keywords

  • 1-LOD support interval
  • Aggressive disease
  • Genetic burden
  • Genetic susceptibility
  • HPC2/ELAC2
  • Metastases

ASJC Scopus subject areas

  • Oncology
  • Urology

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    Baffoe-Bonnie, A. B., Kittles, R. A., Gillanders, E., Ou, L., George, A., Robbins, C., Ahaghotu, C., Bennett, J., Boykin, W., Hoke, G., Mason, T., Pettaway, C., Vijayakumar, S., Weinrich, S., Jones, M. P., Gildea, D., Riedesel, E., Albertus, J., Moses, T., ... Carpten, J. D. (2007). Genome-wide linkage of 77 families from the African American Hereditary Prostate Cancer Study (AAHPC). Prostate, 67(1), 22-31. https://doi.org/10.1002/pros.20456