Genomic actions of 1,25-dihydroxyvitamin D3

G Kerr Whitfield, Jui-Cheng Hsieh, P. W. Jurutka, S. H. Selznick, C. A. Haussler, P. N. MacDonald, Mark R Haussler

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Recent studies have identified a heterodimer of the vitamin D receptor (VDR) and the retinoid X receptor (RXR) as the active complex for mediating positive transcriptional effects of 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], the active hormonal form of vitamin D. The VDR-RXR heterodimer has been shown to bind to direct repeat vitamin D-responsive elements (VDREs) upstream of positively controlled genes in the target tissues for vitamin D, including bone (osteocalcin, osteopontin, and β3 integrin), kidney (24-hydroxylase) and intestine (calbindin). Residues that participate in heterodimer formation have been identified in the C-terminal hormone-binding domain by analysis of VDR mutants. The role of the 1,25(OH)2D3 ligand in transcriptional activation by the VDR-RXR heterodimer is not entirely clear, but studies of two natural VDR mutants suggest that the binding of both hormone and RXR are required to induce a receptor conformation that is competent to activate transcription. A final level of complexity is added by recent observations that VDR is modified by phosphorylation. Thus, the VDR-mediated action of 1,25(OH)2D3 is now known to involve multiple factors that may provide a conceptual basis for future understanding of the tissue-specific genomic effects of 1,25(OH)2D3.

Original languageEnglish (US)
JournalJournal of Nutrition
Volume125
Issue number6 SUPPL.
StatePublished - 1995

Fingerprint

calcitriol
Calcitriol Receptors
Calcitriol
vitamin D
Retinoid X Receptors
genomics
receptors
Vitamin D
retinoids
Hormones
Calbindins
Osteopontin
Nucleic Acid Repetitive Sequences
Osteocalcin
Mixed Function Oxygenases
Integrins
Transcriptional Activation
Intestines
hormones
calbindin

Keywords

  • heterodimers
  • steroid hormone receptors
  • transcriptional regulation
  • vitamin D

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)

Cite this

Whitfield, G. K., Hsieh, J-C., Jurutka, P. W., Selznick, S. H., Haussler, C. A., MacDonald, P. N., & Haussler, M. R. (1995). Genomic actions of 1,25-dihydroxyvitamin D3. Journal of Nutrition, 125(6 SUPPL.).

Genomic actions of 1,25-dihydroxyvitamin D3. / Whitfield, G Kerr; Hsieh, Jui-Cheng; Jurutka, P. W.; Selznick, S. H.; Haussler, C. A.; MacDonald, P. N.; Haussler, Mark R.

In: Journal of Nutrition, Vol. 125, No. 6 SUPPL., 1995.

Research output: Contribution to journalArticle

Whitfield, GK, Hsieh, J-C, Jurutka, PW, Selznick, SH, Haussler, CA, MacDonald, PN & Haussler, MR 1995, 'Genomic actions of 1,25-dihydroxyvitamin D3', Journal of Nutrition, vol. 125, no. 6 SUPPL..
Whitfield GK, Hsieh J-C, Jurutka PW, Selznick SH, Haussler CA, MacDonald PN et al. Genomic actions of 1,25-dihydroxyvitamin D3. Journal of Nutrition. 1995;125(6 SUPPL.).
Whitfield, G Kerr ; Hsieh, Jui-Cheng ; Jurutka, P. W. ; Selznick, S. H. ; Haussler, C. A. ; MacDonald, P. N. ; Haussler, Mark R. / Genomic actions of 1,25-dihydroxyvitamin D3. In: Journal of Nutrition. 1995 ; Vol. 125, No. 6 SUPPL.
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