Genomic Evidence of Local Adaptation to Climate and Diet in Indigenous Siberians

Brian Hallmark, Tatiana Karafet, Ping Hsun Hsieh, Ludmila P. Osipova, Joseph C Watkins, Michael F Hammer

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The indigenous inhabitants of Siberia live in some of the harshest environments on earth, experiencing extended periods of severe cold temperatures, dramatic variation in photoperiod, and limited and highly variable food resources. While the successful long-term settlement of this area by humans required multiple behavioral and cultural innovations, the nature of the underlying genetic changes has generally remained elusive. In this study, we used a three-part approach to identify putative targets of positive natural selection in Siberians. We first performed selection scans on whole exome and genome-wide single nucleotide polymorphism array data from multiple Siberian populations. We then annotated candidates in the tails of the empirical distributions, focusing on candidates with evidence linking them to biological processes and phenotypes previously identified as relevant to adaptation in circumpolar groups. The top candidates were then genotyped in additional populations to determine their spatial allele frequency distributions and associations with climate variables. Our analysis reveals missense mutations in three genes involved in lipid metabolism (PLA2G2A, PLIN1, and ANGPTL8) that exhibit genomic and spatial patterns consistent with selection for cold climate and/or diet. These variants are unified by their connection to brown adipose tissue and may help to explain previously observed physiological differences in Siberians such as low serum lipid levels and increased basal metabolic rate. These results support the hypothesis that indigenous Siberians have genetically adapted to their local environment by selection on multiple genes.

Original languageEnglish (US)
Pages (from-to)315-327
Number of pages13
JournalMolecular biology and evolution
Volume36
Issue number2
DOIs
StatePublished - Feb 1 2019

Fingerprint

local adaptation
Climate
genomics
diet
Cold Climate
Siberia
Diet
Exome
climate
Biological Phenomena
Basal Metabolism
missense mutation
Brown Adipose Tissue
brown adipose tissue
basal metabolic rate
Genetic Selection
cold zones
Photoperiod
Missense Mutation
lipid

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics

Cite this

Genomic Evidence of Local Adaptation to Climate and Diet in Indigenous Siberians. / Hallmark, Brian; Karafet, Tatiana; Hsieh, Ping Hsun; Osipova, Ludmila P.; Watkins, Joseph C; Hammer, Michael F.

In: Molecular biology and evolution, Vol. 36, No. 2, 01.02.2019, p. 315-327.

Research output: Contribution to journalArticle

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