Genotipicheskie razlichiia v metabolizme dofamina mozga i dofaminzavisimykh formakh povedeniia u mysheǐ.

Translated title of the contribution: Genotypic differences in the metabolism of brain dopamine and in the dopamine-dependent forms of behavior in mice

I. A. Skrinskaia, E. M. Nikulina

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Metabolism of dopamine in striatum and the dopamine-dependent forms of behaviour of 6 inbred mice were studied. Interstrain significant differences were shown in the level of dopamine metabolite, homovanillic acid (HVA), as well as in locomotor activity and climbing produced by injection of dopamine agonist apomorphine. Significant negative correlation between the level of HVA in striatum and spontaneous locomotor activity was found. Different levels of HVA and significant behavioural differences were discovered in two similar strains--BALB/c and CC57BR. According to its behavioural characteristics, DBA/2 should also be considered among the most interesting.

Translated title of the contributionGenotypic differences in the metabolism of brain dopamine and in the dopamine-dependent forms of behavior in mice
Original languageRussian
Pages (from-to)1321-1324
Number of pages4
JournalGenetika
Volume24
Issue number7
StatePublished - Jul 1 1988
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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