Gentamicin sulfate attachment and release from anodized Ti‐6Al‐4V orthopedic materials

D. S. Dunn, S. Raghavan, R. G. Volz

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

A novel method has been developed to attach, retain, and release antibiotics from titanium based materials. This technique consists of forming porous surface coatings by anodizing and using the surface chemical properties of the oxide coatings to attach antibiotics. Coatings with pores in the size range 0.1–0.5 μm have been formed in acid solutions. The attachment and retainment of gentamicin sulfate, a cationic antibiotic, to the coatings has been investigated using microbiological methods. In vitro test results have shown that the duration of antimicrobial activity on the surface of anodized materials is dependent on the porosity and isoelectric point of the coatings. Using microporous oxide coatings formed in phosphoric acid solutions, it has been found that antimicrobial activity could be retained for more than 2 weeks. © 1993 John Wiley & Sons, Inc.

Original languageEnglish (US)
Pages (from-to)895-900
Number of pages6
JournalJournal of Biomedical Materials Research
Volume27
Issue number7
DOIs
StatePublished - Jul 1993

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering

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