Germinal centre hyperplasia: An unfavourable immune response in recurrent malignant melanoma

Eric Pihl, B. Jansson, M. A. Schwartz, M. A. Malahy, J. L. Smith, J. V. Gutterman, Evan M Hersh

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A quantitative immunomorphological analysis of actively responding B-(germinal centre) and T-lymphocyte (para-cortical) areas in 187 patients with malignant melanoma recurrent in the regional lymph nodes has been made. The results show that tumour involved nodes have significantly increased germinal centre and decreased paracortical response in comparison with uninvolved lymph nodes. Patients treated with surgery alone whose uninvolved nodes had hyperplastic (defined as exceeding the median) germinal centre areas, had significantly shorter survival than those without germinal centre hyperplasia. No association was found between lymph node immunomorphology and survival in BCG treated patients.

Original languageEnglish (US)
Pages (from-to)13-16
Number of pages4
JournalPathology
Volume14
Issue number1
DOIs
StatePublished - 1982
Externally publishedYes

Fingerprint

Germinal Center
Hyperplasia
Melanoma
Lymph Nodes
Blastodisc
Survival
Mycobacterium bovis
T-Lymphocytes
Neoplasms

Keywords

  • Germinal centres
  • Lymph nodes
  • Melanoma
  • Prognosis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Pihl, E., Jansson, B., Schwartz, M. A., Malahy, M. A., Smith, J. L., Gutterman, J. V., & Hersh, E. M. (1982). Germinal centre hyperplasia: An unfavourable immune response in recurrent malignant melanoma. Pathology, 14(1), 13-16. https://doi.org/10.3109/00313028209069037

Germinal centre hyperplasia : An unfavourable immune response in recurrent malignant melanoma. / Pihl, Eric; Jansson, B.; Schwartz, M. A.; Malahy, M. A.; Smith, J. L.; Gutterman, J. V.; Hersh, Evan M.

In: Pathology, Vol. 14, No. 1, 1982, p. 13-16.

Research output: Contribution to journalArticle

Pihl, E, Jansson, B, Schwartz, MA, Malahy, MA, Smith, JL, Gutterman, JV & Hersh, EM 1982, 'Germinal centre hyperplasia: An unfavourable immune response in recurrent malignant melanoma', Pathology, vol. 14, no. 1, pp. 13-16. https://doi.org/10.3109/00313028209069037
Pihl E, Jansson B, Schwartz MA, Malahy MA, Smith JL, Gutterman JV et al. Germinal centre hyperplasia: An unfavourable immune response in recurrent malignant melanoma. Pathology. 1982;14(1):13-16. https://doi.org/10.3109/00313028209069037
Pihl, Eric ; Jansson, B. ; Schwartz, M. A. ; Malahy, M. A. ; Smith, J. L. ; Gutterman, J. V. ; Hersh, Evan M. / Germinal centre hyperplasia : An unfavourable immune response in recurrent malignant melanoma. In: Pathology. 1982 ; Vol. 14, No. 1. pp. 13-16.
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