Germinal centre hyperplasia: An unfavourable immune response in recurrent malignant melanoma

Eric Pihl, B. Jansson, M. A. Schwartz, M. A. Malahy, J. L. Smith, J. V. Gutterman, E. M. Hersh

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

A quantitative immunomorphological analysis of actively responding B-(germinal centre) and T-lymphocyte (para-cortical) areas in 187 patients with malignant melanoma recurrent in the regional lymph nodes has been made. The results show that tumour involved nodes have significantly increased germinal centre and decreased paracortical response in comparison with uninvolved lymph nodes. Patients treated with surgery alone whose uninvolved nodes had hyperplastic (defined as exceeding the median) germinal centre areas, had significantly shorter survival than those without germinal centre hyperplasia. No association was found between lymph node immunomorphology and survival in BCG treated patients.

Original languageEnglish (US)
Pages (from-to)13-16
Number of pages4
JournalPathology
Volume14
Issue number1
DOIs
StatePublished - Jan 1 1982

Keywords

  • Germinal centres
  • Lymph nodes
  • Melanoma
  • Prognosis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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    Pihl, E., Jansson, B., Schwartz, M. A., Malahy, M. A., Smith, J. L., Gutterman, J. V., & Hersh, E. M. (1982). Germinal centre hyperplasia: An unfavourable immune response in recurrent malignant melanoma. Pathology, 14(1), 13-16. https://doi.org/10.3109/00313028209069037