Getting to the heart of tissue engineering.

Luda Khait; Louise Hecker; Nicole R. Blan; Garrett Coyan; Francesco Migneco; Yen Chih Huang; Ravi K. Birla

doi:10.1007/s12265-007-9005-x

Getting to the heart of tissue engineering.

Luda Khait, Louise Hecker, Nicole R. Blan, Garrett Coyan, Francesco Migneco, Yen Chih Huang, Ravi K. Birla

Research output: Contribution to journal › Review article › peer-review

14 Scopus citations

Abstract

Cardiovascular disease affects 80 million people in the USA and is the leading cause of death. Significant limitations of current treatments necessitate the development of novel strategies. Cardiovascular tissue engineering is an emerging field focused on the development of biological substitutes to restore, maintain, or improve tissue function. In this article, we present an overview of trends in the field and scientific milestones achieved during the last decade. Various 3D bioengineered models of functional cardiovascular structures, including cell-based cardiac pumps, ventricles, patches, vessels, and valves, are described. We discuss critical technological hurdles that must be addressed for continued progress and an outlook for the future of cardiovascular tissue engineering.

Original language	English (US)
Pages (from-to)	71-84
Number of pages	14
Journal	Journal of cardiovascular translational research
Volume	1
Issue number	1
DOIs	https://doi.org/10.1007/s12265-007-9005-x
State	Published - Mar 2008
Externally published	Yes

ASJC Scopus subject areas

Molecular Medicine
Genetics
Pharmaceutical Science
Cardiology and Cardiovascular Medicine
Genetics(clinical)

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abstract = "Cardiovascular disease affects 80 million people in the USA and is the leading cause of death. Significant limitations of current treatments necessitate the development of novel strategies. Cardiovascular tissue engineering is an emerging field focused on the development of biological substitutes to restore, maintain, or improve tissue function. In this article, we present an overview of trends in the field and scientific milestones achieved during the last decade. Various 3D bioengineered models of functional cardiovascular structures, including cell-based cardiac pumps, ventricles, patches, vessels, and valves, are described. We discuss critical technological hurdles that must be addressed for continued progress and an outlook for the future of cardiovascular tissue engineering.",

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