Abstract
Cardiovascular disease affects 80 million people in the USA and is the leading cause of death. Significant limitations of current treatments necessitate the development of novel strategies. Cardiovascular tissue engineering is an emerging field focused on the development of biological substitutes to restore, maintain, or improve tissue function. In this article, we present an overview of trends in the field and scientific milestones achieved during the last decade. Various 3D bioengineered models of functional cardiovascular structures, including cell-based cardiac pumps, ventricles, patches, vessels, and valves, are described. We discuss critical technological hurdles that must be addressed for continued progress and an outlook for the future of cardiovascular tissue engineering.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 71-84 |
| Number of pages | 14 |
| Journal | Journal of Cardiovascular Translational Research |
| Volume | 1 |
| Issue number | 1 |
| DOIs | |
| State | Published - Mar 2008 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Genetics
- Genetics(clinical)
- Molecular Medicine
- Pharmaceutical Science
Cite this
Getting to the heart of tissue engineering. / Khait, Luda; Hecker, Louise; Blan, Nicole R.; Coyan, Garrett; Migneco, Francesco; Huang, Yen Chih; Birla, Ravi K.
In: Journal of Cardiovascular Translational Research, Vol. 1, No. 1, 03.2008, p. 71-84.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Getting to the heart of tissue engineering.
AU - Khait, Luda
AU - Hecker, Louise
AU - Blan, Nicole R.
AU - Coyan, Garrett
AU - Migneco, Francesco
AU - Huang, Yen Chih
AU - Birla, Ravi K.
PY - 2008/3
Y1 - 2008/3
N2 - Cardiovascular disease affects 80 million people in the USA and is the leading cause of death. Significant limitations of current treatments necessitate the development of novel strategies. Cardiovascular tissue engineering is an emerging field focused on the development of biological substitutes to restore, maintain, or improve tissue function. In this article, we present an overview of trends in the field and scientific milestones achieved during the last decade. Various 3D bioengineered models of functional cardiovascular structures, including cell-based cardiac pumps, ventricles, patches, vessels, and valves, are described. We discuss critical technological hurdles that must be addressed for continued progress and an outlook for the future of cardiovascular tissue engineering.
AB - Cardiovascular disease affects 80 million people in the USA and is the leading cause of death. Significant limitations of current treatments necessitate the development of novel strategies. Cardiovascular tissue engineering is an emerging field focused on the development of biological substitutes to restore, maintain, or improve tissue function. In this article, we present an overview of trends in the field and scientific milestones achieved during the last decade. Various 3D bioengineered models of functional cardiovascular structures, including cell-based cardiac pumps, ventricles, patches, vessels, and valves, are described. We discuss critical technological hurdles that must be addressed for continued progress and an outlook for the future of cardiovascular tissue engineering.
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UR - http://www.scopus.com/inward/citedby.url?scp=77957916153&partnerID=8YFLogxK
U2 - 10.1007/s12265-007-9005-x
DO - 10.1007/s12265-007-9005-x
M3 - Article
C2 - 20559960
AN - SCOPUS:77957916153
VL - 1
SP - 71
EP - 84
JO - Journal of Cardiovascular Translational Research
JF - Journal of Cardiovascular Translational Research
SN - 1937-5387
IS - 1
ER -