Getting to the heart of tissue engineering.

Luda Khait, Louise Hecker, Nicole R. Blan, Garrett Coyan, Francesco Migneco, Yen Chih Huang, Ravi K. Birla

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Cardiovascular disease affects 80 million people in the USA and is the leading cause of death. Significant limitations of current treatments necessitate the development of novel strategies. Cardiovascular tissue engineering is an emerging field focused on the development of biological substitutes to restore, maintain, or improve tissue function. In this article, we present an overview of trends in the field and scientific milestones achieved during the last decade. Various 3D bioengineered models of functional cardiovascular structures, including cell-based cardiac pumps, ventricles, patches, vessels, and valves, are described. We discuss critical technological hurdles that must be addressed for continued progress and an outlook for the future of cardiovascular tissue engineering.

Original languageEnglish (US)
Pages (from-to)71-84
Number of pages14
JournalJournal of Cardiovascular Translational Research
Volume1
Issue number1
DOIs
StatePublished - Mar 2008
Externally publishedYes

Fingerprint

Tissue Engineering
Cardiovascular Models
Heart Ventricles
Cause of Death
Cardiovascular Diseases

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Genetics
  • Genetics(clinical)
  • Molecular Medicine
  • Pharmaceutical Science

Cite this

Khait, L., Hecker, L., Blan, N. R., Coyan, G., Migneco, F., Huang, Y. C., & Birla, R. K. (2008). Getting to the heart of tissue engineering. Journal of Cardiovascular Translational Research, 1(1), 71-84. https://doi.org/10.1007/s12265-007-9005-x

Getting to the heart of tissue engineering. / Khait, Luda; Hecker, Louise; Blan, Nicole R.; Coyan, Garrett; Migneco, Francesco; Huang, Yen Chih; Birla, Ravi K.

In: Journal of Cardiovascular Translational Research, Vol. 1, No. 1, 03.2008, p. 71-84.

Research output: Contribution to journalArticle

Khait, L, Hecker, L, Blan, NR, Coyan, G, Migneco, F, Huang, YC & Birla, RK 2008, 'Getting to the heart of tissue engineering.', Journal of Cardiovascular Translational Research, vol. 1, no. 1, pp. 71-84. https://doi.org/10.1007/s12265-007-9005-x
Khait, Luda ; Hecker, Louise ; Blan, Nicole R. ; Coyan, Garrett ; Migneco, Francesco ; Huang, Yen Chih ; Birla, Ravi K. / Getting to the heart of tissue engineering. In: Journal of Cardiovascular Translational Research. 2008 ; Vol. 1, No. 1. pp. 71-84.
@article{cdda5d3e9278430dbbd3d3677a4889f4,
title = "Getting to the heart of tissue engineering.",
abstract = "Cardiovascular disease affects 80 million people in the USA and is the leading cause of death. Significant limitations of current treatments necessitate the development of novel strategies. Cardiovascular tissue engineering is an emerging field focused on the development of biological substitutes to restore, maintain, or improve tissue function. In this article, we present an overview of trends in the field and scientific milestones achieved during the last decade. Various 3D bioengineered models of functional cardiovascular structures, including cell-based cardiac pumps, ventricles, patches, vessels, and valves, are described. We discuss critical technological hurdles that must be addressed for continued progress and an outlook for the future of cardiovascular tissue engineering.",
author = "Luda Khait and Louise Hecker and Blan, {Nicole R.} and Garrett Coyan and Francesco Migneco and Huang, {Yen Chih} and Birla, {Ravi K.}",
year = "2008",
month = "3",
doi = "10.1007/s12265-007-9005-x",
language = "English (US)",
volume = "1",
pages = "71--84",
journal = "Journal of Cardiovascular Translational Research",
issn = "1937-5387",
publisher = "Springer New York",
number = "1",

}

TY - JOUR

T1 - Getting to the heart of tissue engineering.

AU - Khait, Luda

AU - Hecker, Louise

AU - Blan, Nicole R.

AU - Coyan, Garrett

AU - Migneco, Francesco

AU - Huang, Yen Chih

AU - Birla, Ravi K.

PY - 2008/3

Y1 - 2008/3

N2 - Cardiovascular disease affects 80 million people in the USA and is the leading cause of death. Significant limitations of current treatments necessitate the development of novel strategies. Cardiovascular tissue engineering is an emerging field focused on the development of biological substitutes to restore, maintain, or improve tissue function. In this article, we present an overview of trends in the field and scientific milestones achieved during the last decade. Various 3D bioengineered models of functional cardiovascular structures, including cell-based cardiac pumps, ventricles, patches, vessels, and valves, are described. We discuss critical technological hurdles that must be addressed for continued progress and an outlook for the future of cardiovascular tissue engineering.

AB - Cardiovascular disease affects 80 million people in the USA and is the leading cause of death. Significant limitations of current treatments necessitate the development of novel strategies. Cardiovascular tissue engineering is an emerging field focused on the development of biological substitutes to restore, maintain, or improve tissue function. In this article, we present an overview of trends in the field and scientific milestones achieved during the last decade. Various 3D bioengineered models of functional cardiovascular structures, including cell-based cardiac pumps, ventricles, patches, vessels, and valves, are described. We discuss critical technological hurdles that must be addressed for continued progress and an outlook for the future of cardiovascular tissue engineering.

UR - http://www.scopus.com/inward/record.url?scp=77957916153&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77957916153&partnerID=8YFLogxK

U2 - 10.1007/s12265-007-9005-x

DO - 10.1007/s12265-007-9005-x

M3 - Article

C2 - 20559960

AN - SCOPUS:77957916153

VL - 1

SP - 71

EP - 84

JO - Journal of Cardiovascular Translational Research

JF - Journal of Cardiovascular Translational Research

SN - 1937-5387

IS - 1

ER -