GILT: Shaping the MHC class II-restricted peptidome and CD4+ T cell-mediated immunity

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19 Scopus citations

Abstract

The MHC class II-restricted antigen processing pathway generates peptide:MHC complexes in the endocytic pathway for the activation of CD4+ T cells. Gamma-interferon-inducible lysosomal thiol reductase (GILT) reduces protein disulfide bonds in the endocytic compartment, thereby exposing buried epitopes for MHC class II binding and presentation. T cell hybridoma responses and elution of MHC class II bound peptides have identified GILT-dependent epitopes, GILT-independent epitopes, and epitopes that are more efficiently presented in the absence of GILT termed GILT-prevented epitopes. GILT-mediated alteration in the MHC class II-restricted peptidome modulates T cell development in the thymus and peripheral tolerance and influences the pathogenesis of autoimmunity. Recent studies suggest an emerging role for GILT in the response to pathogens and cancer survival.

Original languageEnglish (US)
Article numberArticle 429
JournalFrontiers in immunology
Volume4
Issue numberDEC
DOIs
StatePublished - 2013

Keywords

  • Antigen processing and presentation
  • Autoimmunity
  • GILT
  • MHC class II
  • Tumor immunity

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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