Global mapping of gene/protein interactions in PubMed abstracts: A framework and an experiment with P53 interactions

Xin Li, Hsinchun Chen, Zan Huang, Hua Su, Jesse D. Martinez

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Gene/protein interactions provide critical information for a thorough understanding of cellular processes. Recently, considerable interest and effort has been focused on the construction and analysis of genome-wide gene networks. The large body of biomedical literature is an important source of gene/protein interaction information. Recent advances in text mining tools have made it possible to automatically extract such documented interactions from free-text literature. In this paper, we propose a comprehensive framework for constructing and analyzing large-scale gene functional networks based on the gene/protein interactions extracted from biomedical literature repositories using text mining tools. Our proposed framework consists of analyses of the network topology, network topology-gene function relationship, and temporal network evolution to distill valuable information embedded in the gene functional interactions in the literature. We demonstrate the application of the proposed framework using a testbed of P53-related PubMed abstracts, which shows that the literature-based P53 networks exhibit small-world and scale-free properties. We also found that high degree genes in the literature-based networks have a high probability of appearing in the manually curated database and genes in the same pathway tend to form local clusters in our literature-based networks. Temporal analysis showed that genes interacting with many other genes tend to be involved in a large number of newly discovered interactions.

Original languageEnglish (US)
Pages (from-to)453-464
Number of pages12
JournalJournal of Biomedical Informatics
Volume40
Issue number5
DOIs
StatePublished - Oct 1 2007

Keywords

  • Gene functional network
  • Network analysis
  • Text mining

ASJC Scopus subject areas

  • Computer Science Applications
  • Health Informatics

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