Global variation in the genetic and biochemical basis of diamondback moth resistance to Bacillus thuringiensis

Bruce E Tabashnik, Yong Biao Liu, Thomas Malvar, David G. Heckel, Luke Masson, Victoria Ballester, Francisco Granero, José L. Ménsua, Juan Ferré

Research output: Contribution to journalArticle

167 Citations (Scopus)

Abstract

Insecticidal proteins from the soil bacterium Bacillus thuringiensis (Bt) are becoming n cornerstone of ecologically sound pest management. However, if pests quickly adapt, the benefits of environmentally benign Bt toxins in sprays and genetically engineered crops will be short-lived. The diamondback moth (Plutella xylostella) is the first insect to evolve resistance to Bt in open-field populations. Here we report that populations from Hawaii and Pennsylvania share a genetic locus at which a recessive mutation associated with reduced toxin binding confers extremely high resistance to four Bt toxins. In contrast, resistance in a population from the Philippines shows multilocus control, a narrower spectrum, and for some Bt toxins, inheritance that is not recessive and not associated with reduced binding. The observed variation in the genetic and biochemical basis of resistance to Bt, which is unlike patterns documented for some synthetic insecticides, profoundly affects the choice of strategies for combating resistance.

Original languageEnglish (US)
Pages (from-to)12780-12785
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume94
Issue number24
DOIs
StatePublished - Nov 25 1997

Fingerprint

Bacillus thuringiensis
Moths
Molecular Biology
Population
Pest Control
Genetic Loci
Philippines
Insecticides
Insects
Soil
Bacteria
Mutation
Proteins

ASJC Scopus subject areas

  • Genetics
  • General

Cite this

Global variation in the genetic and biochemical basis of diamondback moth resistance to Bacillus thuringiensis. / Tabashnik, Bruce E; Liu, Yong Biao; Malvar, Thomas; Heckel, David G.; Masson, Luke; Ballester, Victoria; Granero, Francisco; Ménsua, José L.; Ferré, Juan.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, No. 24, 25.11.1997, p. 12780-12785.

Research output: Contribution to journalArticle

Tabashnik, Bruce E ; Liu, Yong Biao ; Malvar, Thomas ; Heckel, David G. ; Masson, Luke ; Ballester, Victoria ; Granero, Francisco ; Ménsua, José L. ; Ferré, Juan. / Global variation in the genetic and biochemical basis of diamondback moth resistance to Bacillus thuringiensis. In: Proceedings of the National Academy of Sciences of the United States of America. 1997 ; Vol. 94, No. 24. pp. 12780-12785.
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