TY - JOUR
T1 - Global virulence regulation networks in phytopathogenic bacteria
AU - Mole, Beth M.
AU - Baltrus, David A.
AU - Dangl, Jeffery L.
AU - Grant, Sarah R.
N1 - Funding Information:
We thank Marc Nishimura, Amy Charkowski, Caitilyn Allen and Max Dow for unpublished photographs. Thanks to Caitilyn Allen, Amy Charkowski and the reviewers for their helpful and constructive comments. J.L.D. is supported by NIH grant 5-RO1-GM06625, DOE grant DE-FG02–95ER20187 and NSF grant IOB-0114795, SRG is supported by NSF grants IOB-0416952 and BE-0412599.
PY - 2007/8
Y1 - 2007/8
N2 - Phytopathogens coordinate multifaceted life histories and deploy stratified virulence determinants via complex, global regulation networks. We dissect the global regulation of four distantly related model phytopathogens to evaluate large-scale events and mechanisms that determine successful pathogenesis. Overarching themes include dependence on centralized cell-to-cell communication systems, pervasive two-component signal-transduction systems, post-transcriptional regulation systems, AraC-like regulators and sigma factors. Although these common regulatory systems control virulence, each functions in different capacities, and to differing ends, in the diverse species. Hence, the virulence regulation network of each species determines its survival and success in various life histories and niches.
AB - Phytopathogens coordinate multifaceted life histories and deploy stratified virulence determinants via complex, global regulation networks. We dissect the global regulation of four distantly related model phytopathogens to evaluate large-scale events and mechanisms that determine successful pathogenesis. Overarching themes include dependence on centralized cell-to-cell communication systems, pervasive two-component signal-transduction systems, post-transcriptional regulation systems, AraC-like regulators and sigma factors. Although these common regulatory systems control virulence, each functions in different capacities, and to differing ends, in the diverse species. Hence, the virulence regulation network of each species determines its survival and success in various life histories and niches.
UR - http://www.scopus.com/inward/record.url?scp=34547176755&partnerID=8YFLogxK
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U2 - 10.1016/j.tim.2007.06.005
DO - 10.1016/j.tim.2007.06.005
M3 - Review article
C2 - 17627825
AN - SCOPUS:34547176755
VL - 15
SP - 363
EP - 371
JO - Trends in Microbiology
JF - Trends in Microbiology
SN - 0966-842X
IS - 8
ER -