Global virulence regulation networks in phytopathogenic bacteria

Beth M. Mole; David A. Baltrus; Jeffery L. Dangl; Sarah R. Grant

doi:10.1016/j.tim.2007.06.005

Global virulence regulation networks in phytopathogenic bacteria

Beth M. Mole, David A. Baltrus, Jeffery L. Dangl, Sarah R. Grant

Research output: Contribution to journal › Review article

101 Scopus citations

Abstract

Phytopathogens coordinate multifaceted life histories and deploy stratified virulence determinants via complex, global regulation networks. We dissect the global regulation of four distantly related model phytopathogens to evaluate large-scale events and mechanisms that determine successful pathogenesis. Overarching themes include dependence on centralized cell-to-cell communication systems, pervasive two-component signal-transduction systems, post-transcriptional regulation systems, AraC-like regulators and sigma factors. Although these common regulatory systems control virulence, each functions in different capacities, and to differing ends, in the diverse species. Hence, the virulence regulation network of each species determines its survival and success in various life histories and niches.

Original language	English (US)
Pages (from-to)	363-371
Number of pages	9
Journal	Trends in Microbiology
Volume	15
Issue number	8
DOIs	https://doi.org/10.1016/j.tim.2007.06.005
State	Published - Aug 1 2007
Externally published	Yes

ASJC Scopus subject areas

Microbiology
Microbiology (medical)
Infectious Diseases
Virology

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10.1016/j.tim.2007.06.005

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Mole, B. M., Baltrus, D. A., Dangl, J. L., & Grant, S. R. (2007). Global virulence regulation networks in phytopathogenic bacteria. Trends in Microbiology, 15(8), 363-371. https://doi.org/10.1016/j.tim.2007.06.005

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