Globosumones A-C, cytotoxic orsellinic acid esters from the sonoran desert endophytic fungus Chaetomium globosum

Bharat P. Bashyal; E. M. Kithsiri Wijeratne; Stanley H. Faeth; A. A.Leslie Gunatilaka

doi:10.1021/np058014b

Globosumones A-C, cytotoxic orsellinic acid esters from the sonoran desert endophytic fungus Chaetomium globosum

Bharat P. Bashyal, E. M. Kithsiri Wijeratne, Stanley H. Faeth, A. A.Leslie Gunatilaka

Natural Resources and the Environment, School of

Research output: Contribution to journal › Article › peer-review

78 Scopus citations

Abstract

Three new esters of orsellinic acid, globosumones A-C (1-3), and three known compounds, orsellinic acid (4), orcinol, and trichodion (5), were isolated from Chaetomium globosum endophytic on Ephedra fasciculata (Mormon tea). The structures of the new compounds 1-3 were established spectroscopically, which included 2D NMK experiments and ¹H NMK studies on Mosher's ester derivatives. All compounds were evaluated for inhibition of cell proliferation in a panel of four cancer cell lines, NCI-H460 (non-small cell lung cancer), MCF-7 (breast cancer), SF-268 (CNS glioma), and MIA Pa Ca-2 (pancreatic carcinoma), and normal human fibroblast cells (WI-38). Only globosumones A (1) and B (2) were found to be moderately active.

Original language	English (US)
Pages (from-to)	724-728
Number of pages	5
Journal	Journal Of Natural Products
Volume	68
Issue number	5
DOIs	https://doi.org/10.1021/np058014b
State	Published - May 2005

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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title = "Globosumones A-C, cytotoxic orsellinic acid esters from the sonoran desert endophytic fungus Chaetomium globosum",

abstract = "Three new esters of orsellinic acid, globosumones A-C (1-3), and three known compounds, orsellinic acid (4), orcinol, and trichodion (5), were isolated from Chaetomium globosum endophytic on Ephedra fasciculata (Mormon tea). The structures of the new compounds 1-3 were established spectroscopically, which included 2D NMK experiments and 1H NMK studies on Mosher's ester derivatives. All compounds were evaluated for inhibition of cell proliferation in a panel of four cancer cell lines, NCI-H460 (non-small cell lung cancer), MCF-7 (breast cancer), SF-268 (CNS glioma), and MIA Pa Ca-2 (pancreatic carcinoma), and normal human fibroblast cells (WI-38). Only globosumones A (1) and B (2) were found to be moderately active.",

author = "Bashyal, {Bharat P.} and {Kithsiri Wijeratne}, {E. M.} and Faeth, {Stanley H.} and Gunatilaka, {A. A.Leslie}",

year = "2005",

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doi = "10.1021/np058014b",

language = "English (US)",

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journal = "Journal of Natural Products",

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T1 - Globosumones A-C, cytotoxic orsellinic acid esters from the sonoran desert endophytic fungus Chaetomium globosum

AU - Bashyal, Bharat P.

AU - Kithsiri Wijeratne, E. M.

AU - Faeth, Stanley H.

AU - Gunatilaka, A. A.Leslie

PY - 2005/5

Y1 - 2005/5

N2 - Three new esters of orsellinic acid, globosumones A-C (1-3), and three known compounds, orsellinic acid (4), orcinol, and trichodion (5), were isolated from Chaetomium globosum endophytic on Ephedra fasciculata (Mormon tea). The structures of the new compounds 1-3 were established spectroscopically, which included 2D NMK experiments and 1H NMK studies on Mosher's ester derivatives. All compounds were evaluated for inhibition of cell proliferation in a panel of four cancer cell lines, NCI-H460 (non-small cell lung cancer), MCF-7 (breast cancer), SF-268 (CNS glioma), and MIA Pa Ca-2 (pancreatic carcinoma), and normal human fibroblast cells (WI-38). Only globosumones A (1) and B (2) were found to be moderately active.

AB - Three new esters of orsellinic acid, globosumones A-C (1-3), and three known compounds, orsellinic acid (4), orcinol, and trichodion (5), were isolated from Chaetomium globosum endophytic on Ephedra fasciculata (Mormon tea). The structures of the new compounds 1-3 were established spectroscopically, which included 2D NMK experiments and 1H NMK studies on Mosher's ester derivatives. All compounds were evaluated for inhibition of cell proliferation in a panel of four cancer cell lines, NCI-H460 (non-small cell lung cancer), MCF-7 (breast cancer), SF-268 (CNS glioma), and MIA Pa Ca-2 (pancreatic carcinoma), and normal human fibroblast cells (WI-38). Only globosumones A (1) and B (2) were found to be moderately active.

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