Abstract
Three new esters of orsellinic acid, globosumones A-C (1-3), and three known compounds, orsellinic acid (4), orcinol, and trichodion (5), were isolated from Chaetomium globosum endophytic on Ephedra fasciculata (Mormon tea). The structures of the new compounds 1-3 were established spectroscopically, which included 2D NMK experiments and 1H NMK studies on Mosher's ester derivatives. All compounds were evaluated for inhibition of cell proliferation in a panel of four cancer cell lines, NCI-H460 (non-small cell lung cancer), MCF-7 (breast cancer), SF-268 (CNS glioma), and MIA Pa Ca-2 (pancreatic carcinoma), and normal human fibroblast cells (WI-38). Only globosumones A (1) and B (2) were found to be moderately active.
Original language | English (US) |
---|---|
Pages (from-to) | 724-728 |
Number of pages | 5 |
Journal | Journal Of Natural Products |
Volume | 68 |
Issue number | 5 |
DOIs | |
State | Published - May 2005 |
ASJC Scopus subject areas
- Analytical Chemistry
- Molecular Medicine
- Pharmacology
- Pharmaceutical Science
- Drug Discovery
- Complementary and alternative medicine
- Organic Chemistry