Glucagon and catecholamine secretion during hypoglycemia in normal and diabetic man

J. W. Benson, David G Johnson, J. P. Palmer, P. L. Werner, J. W. Ensinck

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

To examine the role of catecholamines in glucopenia induced glucagon secretion urinary epinephrine and norepinephrine and plasma immunoreactive glucagon (IRG) were measured during insulin induced hypoglycemia in normal and insulin dependent diabetic man. Despite equivalent levels of hypoglycemia the mean plasma IRG increment in diabetics was only 15% of normals. The increases in epinephrine and norepinephrine were comparable in diabetics and normals; thus, the blunted response in plasma IRG to the stimulus of low blood sugar in diabetics cannot be explained by a generalized defect in catecholamine secretion. It is suggested that an alpha cell glucoreceptor defect may account for the abnormal response to glucopenia in diabetics. To evaluate the possibility that impaired sensitivity to circulating catecholamines could explain the alpha cell dysfunction in diabetics, exogenous epinephrine was infused in normals and insulin dependent diabetics. Elevated plasma IRG during epinephrine infusion was observed in only 50% of normals. The diabetics were hyperresponsive; mean increment in plasma IRG 3 times that of normals. The data demonstrate enhanced rather than impaired sensitivity to catecholamines in diabetes mellitus.

Original languageEnglish (US)
Pages (from-to)459-464
Number of pages6
JournalJournal of Clinical Endocrinology and Metabolism
Volume44
Issue number3
StatePublished - 1977
Externally publishedYes

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Glucagon
Hypoglycemia
Catecholamines
Epinephrine
Plasmas
Insulin
Norepinephrine
Defects
Medical problems
Blood Glucose
Diabetes Mellitus

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Glucagon and catecholamine secretion during hypoglycemia in normal and diabetic man. / Benson, J. W.; Johnson, David G; Palmer, J. P.; Werner, P. L.; Ensinck, J. W.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 44, No. 3, 1977, p. 459-464.

Research output: Contribution to journalArticle

Benson, J. W. ; Johnson, David G ; Palmer, J. P. ; Werner, P. L. ; Ensinck, J. W. / Glucagon and catecholamine secretion during hypoglycemia in normal and diabetic man. In: Journal of Clinical Endocrinology and Metabolism. 1977 ; Vol. 44, No. 3. pp. 459-464.
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