Glycine-based oral rehydration solution: Reassessment of safety and efficacy

Mathuram Santosham, Barbara A. Burns, Raymond Reid, G. William Letson, Burris R Duncan, Jean A. Powlesland, Stephan Foster, Steven Garrett, Larry Croll, Nyunt Nyunt Wai, William N. Marshall, Janne' Almeido-Hill, R. Bradley Sack

Research output: Contribution to journalArticle

33 Scopus citations


We evaluated the safety and efficacy of a glycine-based orally administered rehydration solution by comparing it with a standard oral rehydration solution (ORS) without glycine in a randomized double-blind trial in United States infants (age<15 months) given treatment for acute gastroenteritis as inpatients or outpatients. The response to therapy (stool volume and duration of illness) was similar in the two groups, except that in four (13%) of 31 hospitalized infants receiving glycine-ORS hypernatremia developed, (one had symptoms) compared with none of 35 receiving ORS (P<0.04). Among the 77 outpatients there were no differences between the groups. This study demonstrates that glycine-ORS did not provide any therapeutic advantage over standard ORS, and hypernatremia developed in some patients receiving glycine-ORS. We suggest that caution be used with this type of solution until further safety studies have been done.

Original languageEnglish (US)
Pages (from-to)795-801
Number of pages7
JournalThe Journal of Pediatrics
Issue number5
Publication statusPublished - 1986


ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Santosham, M., Burns, B. A., Reid, R., Letson, G. W., Duncan, B. R., Powlesland, J. A., ... Sack, R. B. (1986). Glycine-based oral rehydration solution: Reassessment of safety and efficacy. The Journal of Pediatrics, 109(5), 795-801.