Glycine-based oral rehydration solution

Reassessment of safety and efficacy

Mathuram Santosham, Barbara A. Burns, Raymond Reid, G. William Letson, Burris R Duncan, Jean A. Powlesland, Stephan Foster, Steven Garrett, Larry Croll, Nyunt Nyunt Wai, William N. Marshall, Janne' Almeido-Hill, R. Bradley Sack

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

We evaluated the safety and efficacy of a glycine-based orally administered rehydration solution by comparing it with a standard oral rehydration solution (ORS) without glycine in a randomized double-blind trial in United States infants (age<15 months) given treatment for acute gastroenteritis as inpatients or outpatients. The response to therapy (stool volume and duration of illness) was similar in the two groups, except that in four (13%) of 31 hospitalized infants receiving glycine-ORS hypernatremia developed, (one had symptoms) compared with none of 35 receiving ORS (P<0.04). Among the 77 outpatients there were no differences between the groups. This study demonstrates that glycine-ORS did not provide any therapeutic advantage over standard ORS, and hypernatremia developed in some patients receiving glycine-ORS. We suggest that caution be used with this type of solution until further safety studies have been done.

Original languageEnglish (US)
Pages (from-to)795-801
Number of pages7
JournalThe Journal of Pediatrics
Volume109
Issue number5
DOIs
StatePublished - 1986

Fingerprint

Rehydration Solutions
Fluid Therapy
Glycine
Safety
Hypernatremia
Outpatients
Gastroenteritis
Inpatients
Therapeutics

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Santosham, M., Burns, B. A., Reid, R., Letson, G. W., Duncan, B. R., Powlesland, J. A., ... Sack, R. B. (1986). Glycine-based oral rehydration solution: Reassessment of safety and efficacy. The Journal of Pediatrics, 109(5), 795-801. https://doi.org/10.1016/S0022-3476(86)80696-5

Glycine-based oral rehydration solution : Reassessment of safety and efficacy. / Santosham, Mathuram; Burns, Barbara A.; Reid, Raymond; Letson, G. William; Duncan, Burris R; Powlesland, Jean A.; Foster, Stephan; Garrett, Steven; Croll, Larry; Wai, Nyunt Nyunt; Marshall, William N.; Almeido-Hill, Janne'; Sack, R. Bradley.

In: The Journal of Pediatrics, Vol. 109, No. 5, 1986, p. 795-801.

Research output: Contribution to journalArticle

Santosham, M, Burns, BA, Reid, R, Letson, GW, Duncan, BR, Powlesland, JA, Foster, S, Garrett, S, Croll, L, Wai, NN, Marshall, WN, Almeido-Hill, J & Sack, RB 1986, 'Glycine-based oral rehydration solution: Reassessment of safety and efficacy', The Journal of Pediatrics, vol. 109, no. 5, pp. 795-801. https://doi.org/10.1016/S0022-3476(86)80696-5
Santosham, Mathuram ; Burns, Barbara A. ; Reid, Raymond ; Letson, G. William ; Duncan, Burris R ; Powlesland, Jean A. ; Foster, Stephan ; Garrett, Steven ; Croll, Larry ; Wai, Nyunt Nyunt ; Marshall, William N. ; Almeido-Hill, Janne' ; Sack, R. Bradley. / Glycine-based oral rehydration solution : Reassessment of safety and efficacy. In: The Journal of Pediatrics. 1986 ; Vol. 109, No. 5. pp. 795-801.
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