Glycosaminoglycans inhibit Candida albicans adherence to extracellular matrix proteins

Stephen A Klotz, Robert L. Smith

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The ability of Candida albicans to adhere to subendothelial extracellular matrix (ECM) may be important in the pathogenesis of disseminated candidiasis. ECM proteins, such as fibronectin, laminin, and types I and IV collagen bind C. albicans avidly. These proteins all posses heparin-binding domains. The influence of the glycosaminoglycans (GAGS) including heparin, heparan sulfate and dextran sulfate on C. albicans adherence to subendothelial ECM and ECM proteins was studies. It was demonstrated that the GAGS inhibited C. albicans adherence to ECM and ECM proteins. This possibly occurred by the GAGS binding to the ECM proteins and, in so doing, masking a preferred ligand for C. albicans adherence.

Original languageEnglish (US)
Pages (from-to)205-208
Number of pages4
JournalFEMS Microbiology Letters
Volume99
Issue number2-3
StatePublished - Dec 1 1992
Externally publishedYes

Fingerprint

Extracellular Matrix Proteins
Glycosaminoglycans
Candida albicans
Extracellular Matrix
Heparin
Dextran Sulfate
Heparitin Sulfate
Collagen Type IV
Candidiasis
Laminin
Collagen Type I
Fibronectins
Ligands
Proteins

Keywords

  • Candida albicans
  • Extracellular matrix
  • Fibronectin
  • Glycosaminoglycan
  • Heparin

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Applied Microbiology and Biotechnology
  • Microbiology

Cite this

Glycosaminoglycans inhibit Candida albicans adherence to extracellular matrix proteins. / Klotz, Stephen A; Smith, Robert L.

In: FEMS Microbiology Letters, Vol. 99, No. 2-3, 01.12.1992, p. 205-208.

Research output: Contribution to journalArticle

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