GO-module: Functional synthesis and improved interpretation of gene ontology patterns

Xinan Yang, Jianrong Li, Younghee Lee, Yves A Lussier

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Summary: GO-Module is a web-accessible synthesis and visualization tool developed for end-user biologists to greatly simplify the interpretation of prioritized Gene Ontology (GO) terms. GO-Module radically reduces the complexity of raw GO results into compact biomodules in two distinct ways, by (i) constructing biomodules from significant GO terms based on hierarchical knowledge, and (ii) refining the GO terms in each biomodule to contain only true positive results. Altogether, the features (biomodules) of GO-Module outputs are better organized and on average four times smaller than the input GO terms list (P = 0.0005, n = 16).

Original languageEnglish (US)
Article numberbtr142
Pages (from-to)1444-1446
Number of pages3
JournalBioinformatics
Volume27
Issue number10
DOIs
StatePublished - May 2011
Externally publishedYes

Fingerprint

Gene Ontology
Gene Regulatory Networks
Ontology
Genes
Synthesis
Module
Term
Interpretation
Refining
Simplify
Visualization
Distinct
Output

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Computational Theory and Mathematics
  • Computer Science Applications
  • Computational Mathematics
  • Statistics and Probability
  • Medicine(all)

Cite this

GO-module : Functional synthesis and improved interpretation of gene ontology patterns. / Yang, Xinan; Li, Jianrong; Lee, Younghee; Lussier, Yves A.

In: Bioinformatics, Vol. 27, No. 10, btr142, 05.2011, p. 1444-1446.

Research output: Contribution to journalArticle

Yang, Xinan ; Li, Jianrong ; Lee, Younghee ; Lussier, Yves A. / GO-module : Functional synthesis and improved interpretation of gene ontology patterns. In: Bioinformatics. 2011 ; Vol. 27, No. 10. pp. 1444-1446.
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