Gonadal steroid actions on brain

S. A. Tobet, R. J. Handa

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Gonadal steroids affect many structures in the brain and other areas of the nervous system. These molecules also undergo metabolism in several brain sites, and the interactions of the resulting products influence brain development, behavior and neuroendocrine function. The brain can be viewed as a second endocrine system in which steroid conversions and cellular actions occur, since it consists of varied regions and cell types, which exhibit a spectrum of metabolic activities. Many expressed proteins and molecular interactions in the nervous system resemble or are the same as those of classically defined endocrine tissues that are selective for different steroids.

Original languageEnglish (US)
Title of host publicationThe Curated Reference Collection in Neuroscience and Biobehavioral Psychology
PublisherElsevier Science Ltd.
Pages951-957
Number of pages7
ISBN (Electronic)9780128093245
DOIs
StatePublished - Jan 1 2016
Externally publishedYes

Keywords

  • Activational
  • Androgen
  • Aromatase
  • Aromatization
  • Defeminization
  • Endocrine disruptors
  • Estrogen
  • Gonadotropin releasing hormone
  • Hypothalamus
  • Luteinizing hormone
  • Masculinization
  • Organizational
  • Phytoestrogens
  • Reductase
  • Steroid receptors

ASJC Scopus subject areas

  • Medicine(all)

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