Gonadal steroid hormone regulation of proopiomelanocortin gene expression in neurons that innervate the median eminence of the rat

Sun Cheung, Ronald P Hammer

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The effect of gonadal steroid hormones on the expression of proopiomelanocortin (POMC) in neurons that innervate the median eminence (ME) was investigated using combined retrograde neuronal labeling and in situ hybridization histochemistry. It was observed that gonadal hormone treatment significantly increased the expression of POMC mRNA. The results suggest that POMC neurons directly innervate the ME, where POMC-derived peptides could rapidly inhibit luteinizing hormone-releasing hormone release following the preovulatory hormone surge.

Original languageEnglish (US)
Pages (from-to)181-184
Number of pages4
JournalNeuroscience Letters
Volume224
Issue number3
DOIs
StatePublished - 1997
Externally publishedYes

Fingerprint

Pro-Opiomelanocortin
Median Eminence
Gene Expression Regulation
Gonadal Steroid Hormones
Neurons
Gonadal Hormones
Gonadotropin-Releasing Hormone
In Situ Hybridization
Hormones
Messenger RNA
Peptides

Keywords

  • β-Endorphin
  • Arcuate nucleus
  • Estrogen
  • Hypothalamus
  • Median eminence
  • Opioid
  • Progesterone
  • Proopiomelanocortin

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

@article{74c09ddde7744312bf1464cb6ae13647,
title = "Gonadal steroid hormone regulation of proopiomelanocortin gene expression in neurons that innervate the median eminence of the rat",
abstract = "The effect of gonadal steroid hormones on the expression of proopiomelanocortin (POMC) in neurons that innervate the median eminence (ME) was investigated using combined retrograde neuronal labeling and in situ hybridization histochemistry. It was observed that gonadal hormone treatment significantly increased the expression of POMC mRNA. The results suggest that POMC neurons directly innervate the ME, where POMC-derived peptides could rapidly inhibit luteinizing hormone-releasing hormone release following the preovulatory hormone surge.",
keywords = "β-Endorphin, Arcuate nucleus, Estrogen, Hypothalamus, Median eminence, Opioid, Progesterone, Proopiomelanocortin",
author = "Sun Cheung and Hammer, {Ronald P}",
year = "1997",
doi = "10.1016/S0304-3940(97)00173-0",
language = "English (US)",
volume = "224",
pages = "181--184",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "3",

}

TY - JOUR

T1 - Gonadal steroid hormone regulation of proopiomelanocortin gene expression in neurons that innervate the median eminence of the rat

AU - Cheung, Sun

AU - Hammer, Ronald P

PY - 1997

Y1 - 1997

N2 - The effect of gonadal steroid hormones on the expression of proopiomelanocortin (POMC) in neurons that innervate the median eminence (ME) was investigated using combined retrograde neuronal labeling and in situ hybridization histochemistry. It was observed that gonadal hormone treatment significantly increased the expression of POMC mRNA. The results suggest that POMC neurons directly innervate the ME, where POMC-derived peptides could rapidly inhibit luteinizing hormone-releasing hormone release following the preovulatory hormone surge.

AB - The effect of gonadal steroid hormones on the expression of proopiomelanocortin (POMC) in neurons that innervate the median eminence (ME) was investigated using combined retrograde neuronal labeling and in situ hybridization histochemistry. It was observed that gonadal hormone treatment significantly increased the expression of POMC mRNA. The results suggest that POMC neurons directly innervate the ME, where POMC-derived peptides could rapidly inhibit luteinizing hormone-releasing hormone release following the preovulatory hormone surge.

KW - β-Endorphin

KW - Arcuate nucleus

KW - Estrogen

KW - Hypothalamus

KW - Median eminence

KW - Opioid

KW - Progesterone

KW - Proopiomelanocortin

UR - http://www.scopus.com/inward/record.url?scp=0030890513&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030890513&partnerID=8YFLogxK

U2 - 10.1016/S0304-3940(97)00173-0

DO - 10.1016/S0304-3940(97)00173-0

M3 - Article

C2 - 9131666

AN - SCOPUS:0030890513

VL - 224

SP - 181

EP - 184

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 3

ER -