Gonadal steroid hormone regulation of proopiomelanocortin gene expression in neurons that innervate the median eminence of the rat

Sun Cheung, Ronald P. Hammer

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

The effect of gonadal steroid hormones on the expression of proopiomelanocortin (POMC) in neurons that innervate the median eminence (ME) was investigated using combined retrograde neuronal labeling and in situ hybridization histochemistry. It was observed that gonadal hormone treatment significantly increased the expression of POMC mRNA. The results suggest that POMC neurons directly innervate the ME, where POMC-derived peptides could rapidly inhibit luteinizing hormone-releasing hormone release following the preovulatory hormone surge.

Original languageEnglish (US)
Pages (from-to)181-184
Number of pages4
JournalNeuroscience Letters
Volume224
Issue number3
DOIs
StatePublished - Apr 10 1997
Externally publishedYes

Keywords

  • Arcuate nucleus
  • Estrogen
  • Hypothalamus
  • Median eminence
  • Opioid
  • Progesterone
  • Proopiomelanocortin
  • β-Endorphin

ASJC Scopus subject areas

  • Neuroscience(all)

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