Gonadal Steroid Hormones and Hypothalamic Opioid Circuitry

Ronald P Hammer, Lei Zhou, Sun Cheung

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Endogenous opioid peptides derived from several gene families are localized within hypothalamic regions known to be involved in the regulation of reproduction. For example, the proenkephalin gene products, met- and leu-enkephalin, and the proopiomelanocortin (POMC) gene product, β-endorphin, are found in the rat medial preoptic area (MPOA). Moreover, the expression of these peptides and their receptors varies across the estrous cycle in the female rat. We have examined the gonadal steroid regulation of μ-opiate receptors and opioid peptides in the MPOA, and POMC mRNA expression in neurons that innervate the MPOA. μ-Opiate receptors in the MPOA are sexually dimorphic and gonadal steroid hormone-dependent. Hormonal priming of ovariectomized rats with estrogen and progesterone (P) upregulates MPOA μ-receptors 27, but not 3, hr after P treatment. Inhibition of protein synthesis during the first 6 hr after P prevents receptor upregulation, The density of β-endorphin fibers in the MPOA also increases following hormone treatment, and POMC mRNA expression in neurons that innervate the MPOA is induced by hormone treatment beginning 13 hr after P treatment. This delayed response might be ubiquitous among POMC neurons, as those innervating the median eminence also exhibit increased POMC mRNA expression along a similar time course. The results suggest that hormonal feedback regulates opioid peptides which act at μ-receptors in the MPOA to influence reproductive behavior and cyclicity. These opioid functions represent an important component in the complex regulatory processes which control reproduction.

Original languageEnglish (US)
Pages (from-to)431-437
Number of pages7
JournalHormones and Behavior
Volume28
Issue number4
DOIs
StatePublished - Dec 1994
Externally publishedYes

Fingerprint

Preoptic Area
Gonadal Steroid Hormones
Opioid Analgesics
Pro-Opiomelanocortin
Opioid Peptides
Endorphins
Opioid Receptors
Neurons
Messenger RNA
Reproduction
Up-Regulation
Hormones
Genes
Leucine Enkephalin
Reproductive Behavior
Methionine Enkephalin
Median Eminence
Peptide Receptors
Estrous Cycle
Periodicity

ASJC Scopus subject areas

  • Psychology(all)
  • Neurology
  • Behavioral Neuroscience
  • Endocrinology

Cite this

Gonadal Steroid Hormones and Hypothalamic Opioid Circuitry. / Hammer, Ronald P; Zhou, Lei; Cheung, Sun.

In: Hormones and Behavior, Vol. 28, No. 4, 12.1994, p. 431-437.

Research output: Contribution to journalArticle

Hammer, Ronald P ; Zhou, Lei ; Cheung, Sun. / Gonadal Steroid Hormones and Hypothalamic Opioid Circuitry. In: Hormones and Behavior. 1994 ; Vol. 28, No. 4. pp. 431-437.
@article{c118f0bc01034ab2bec61658a664d32f,
title = "Gonadal Steroid Hormones and Hypothalamic Opioid Circuitry",
abstract = "Endogenous opioid peptides derived from several gene families are localized within hypothalamic regions known to be involved in the regulation of reproduction. For example, the proenkephalin gene products, met- and leu-enkephalin, and the proopiomelanocortin (POMC) gene product, β-endorphin, are found in the rat medial preoptic area (MPOA). Moreover, the expression of these peptides and their receptors varies across the estrous cycle in the female rat. We have examined the gonadal steroid regulation of μ-opiate receptors and opioid peptides in the MPOA, and POMC mRNA expression in neurons that innervate the MPOA. μ-Opiate receptors in the MPOA are sexually dimorphic and gonadal steroid hormone-dependent. Hormonal priming of ovariectomized rats with estrogen and progesterone (P) upregulates MPOA μ-receptors 27, but not 3, hr after P treatment. Inhibition of protein synthesis during the first 6 hr after P prevents receptor upregulation, The density of β-endorphin fibers in the MPOA also increases following hormone treatment, and POMC mRNA expression in neurons that innervate the MPOA is induced by hormone treatment beginning 13 hr after P treatment. This delayed response might be ubiquitous among POMC neurons, as those innervating the median eminence also exhibit increased POMC mRNA expression along a similar time course. The results suggest that hormonal feedback regulates opioid peptides which act at μ-receptors in the MPOA to influence reproductive behavior and cyclicity. These opioid functions represent an important component in the complex regulatory processes which control reproduction.",
author = "Hammer, {Ronald P} and Lei Zhou and Sun Cheung",
year = "1994",
month = "12",
doi = "10.1006/hbeh.1994.1040",
language = "English (US)",
volume = "28",
pages = "431--437",
journal = "Hormones and Behavior",
issn = "0018-506X",
publisher = "Academic Press Inc.",
number = "4",

}

TY - JOUR

T1 - Gonadal Steroid Hormones and Hypothalamic Opioid Circuitry

AU - Hammer, Ronald P

AU - Zhou, Lei

AU - Cheung, Sun

PY - 1994/12

Y1 - 1994/12

N2 - Endogenous opioid peptides derived from several gene families are localized within hypothalamic regions known to be involved in the regulation of reproduction. For example, the proenkephalin gene products, met- and leu-enkephalin, and the proopiomelanocortin (POMC) gene product, β-endorphin, are found in the rat medial preoptic area (MPOA). Moreover, the expression of these peptides and their receptors varies across the estrous cycle in the female rat. We have examined the gonadal steroid regulation of μ-opiate receptors and opioid peptides in the MPOA, and POMC mRNA expression in neurons that innervate the MPOA. μ-Opiate receptors in the MPOA are sexually dimorphic and gonadal steroid hormone-dependent. Hormonal priming of ovariectomized rats with estrogen and progesterone (P) upregulates MPOA μ-receptors 27, but not 3, hr after P treatment. Inhibition of protein synthesis during the first 6 hr after P prevents receptor upregulation, The density of β-endorphin fibers in the MPOA also increases following hormone treatment, and POMC mRNA expression in neurons that innervate the MPOA is induced by hormone treatment beginning 13 hr after P treatment. This delayed response might be ubiquitous among POMC neurons, as those innervating the median eminence also exhibit increased POMC mRNA expression along a similar time course. The results suggest that hormonal feedback regulates opioid peptides which act at μ-receptors in the MPOA to influence reproductive behavior and cyclicity. These opioid functions represent an important component in the complex regulatory processes which control reproduction.

AB - Endogenous opioid peptides derived from several gene families are localized within hypothalamic regions known to be involved in the regulation of reproduction. For example, the proenkephalin gene products, met- and leu-enkephalin, and the proopiomelanocortin (POMC) gene product, β-endorphin, are found in the rat medial preoptic area (MPOA). Moreover, the expression of these peptides and their receptors varies across the estrous cycle in the female rat. We have examined the gonadal steroid regulation of μ-opiate receptors and opioid peptides in the MPOA, and POMC mRNA expression in neurons that innervate the MPOA. μ-Opiate receptors in the MPOA are sexually dimorphic and gonadal steroid hormone-dependent. Hormonal priming of ovariectomized rats with estrogen and progesterone (P) upregulates MPOA μ-receptors 27, but not 3, hr after P treatment. Inhibition of protein synthesis during the first 6 hr after P prevents receptor upregulation, The density of β-endorphin fibers in the MPOA also increases following hormone treatment, and POMC mRNA expression in neurons that innervate the MPOA is induced by hormone treatment beginning 13 hr after P treatment. This delayed response might be ubiquitous among POMC neurons, as those innervating the median eminence also exhibit increased POMC mRNA expression along a similar time course. The results suggest that hormonal feedback regulates opioid peptides which act at μ-receptors in the MPOA to influence reproductive behavior and cyclicity. These opioid functions represent an important component in the complex regulatory processes which control reproduction.

UR - http://www.scopus.com/inward/record.url?scp=0028561846&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028561846&partnerID=8YFLogxK

U2 - 10.1006/hbeh.1994.1040

DO - 10.1006/hbeh.1994.1040

M3 - Article

VL - 28

SP - 431

EP - 437

JO - Hormones and Behavior

JF - Hormones and Behavior

SN - 0018-506X

IS - 4

ER -