Gonadal steroid hormones upregulate medial preoptic μ-opioid receptors in the rat

Lei Zhou, Ronald P Hammer

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The density of μ-opioid receptors is dependent upon the levels of gonadal steroid hormones in the medial preoptic area of ovariectomized female rats. Because the region containing these cyclical μ-opioid receptors is relatively small, autoradiographic analysis of the binding of a saturating concentration of μ-selective radioligand was used to determine whether hormone treatment affects maximal binding capacity of these receptors. The results reveal that gonadal steroid hormones upregulate μ-opioid receptor binding capacity specifically in the medial preoptic area 27 h later, without affecting binding in adjacent brain regions. This suggests that hormones induce a functional increase of medial preoptic area μ-opioid receptors which could serve to regulate reproductive activities.

Original languageEnglish (US)
Pages (from-to)271-274
Number of pages4
JournalEuropean Journal of Pharmacology
Volume278
Issue number3
DOIs
StatePublished - May 24 1995
Externally publishedYes

Fingerprint

Gonadal Steroid Hormones
Opioid Receptors
Preoptic Area
Up-Regulation
Hormones
Brain

Keywords

  • Estrogen
  • Medial preoptic area
  • Progesterone
  • Upregulation
  • μ-Opioid receptor

ASJC Scopus subject areas

  • Pharmacology
  • Cellular and Molecular Neuroscience

Cite this

Gonadal steroid hormones upregulate medial preoptic μ-opioid receptors in the rat. / Zhou, Lei; Hammer, Ronald P.

In: European Journal of Pharmacology, Vol. 278, No. 3, 24.05.1995, p. 271-274.

Research output: Contribution to journalArticle

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