Gonadotropin deficiency in tourette's syndrome: A preliminary communication

Reuven Sandyk, Colin R. Bamford, Anna Binkiewicz, Paul R. Finley

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Plasma baseline levels of gonadotropins and sex steroids were measured in 17 patients with Tourette's Syndrome (TS). In addition, a Gonadotropin Stimulation test, using a synthetic Gonadotropin releasing factor analogue (GnRH, 100 micrograms, i.v.), was performed in 7 patients. Plasma levels of Luteinizing Hormone (LH) were uniformly low in all patients, while those of Follicle Stimulating hormone (FSH) and sex steroids were less depressed in some patients and in the normal range in others. In all patients, stimulation with GnRH analogue produced a marked rise in LH levels, but the FSH responses were much less dramatic and did not significantly exceed that of normal controls. Our findings indicate reduced gonadotropin release in patients with TS, and support the hypothesis of hypothalamic involvement in the disease.

Original languageEnglish (US)
Pages (from-to)121-125
Number of pages5
JournalInternational Journal of Neuroscience
Volume42
Issue number1-2
DOIs
StatePublished - Jan 1 1988

Keywords

  • Gonadotropin
  • Hypothalumus
  • Tourette's syndrome

ASJC Scopus subject areas

  • Neuroscience(all)

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