The circadian clock in the unicellular alga Gonyaulax polyedra is accelerated by a substance in extracts from the cells themselves. The extracts have been fractionated using the circadian rhythm of bioluminescence as bioassay. The active substance, termed gonyauline, has been isolated and characterized as a novel low molecular weight cyclopropanecarboxylic acid (S-methyl-cis-2-(methylthio) cyclopropanecarboxylic acid). Synthetic gonyauline has a similar shortening effect on the period of the circadian clock.
- Circadian rhythm
- Gonyaulax polyedra
- S-methyl-cis-2-(methylthio) cyclopropanecarboxylic acid
- period length
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)