Gradient-echo imaging of hemorrhage at 1.5 Tesla

Evan C Unger, Mark S. Cohen, Truman R. Brown

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

We report in vitro and in vivo MR studies of hemorrhage using the gradient-echo pulse sequence, FISP (steady state free precession) and FLASH (spoiling of transverse magnetization) at 1.5 Tesla. Phantoms containing methemoglobin, ferromagnetic particles, human serum and blood clot were scanned using both spin-echo and gradient-echo techniques. FLASH signal intensities were more sensitive to methemoglobin concentration than high T1-weighted spin-echo images. FISP showed little change in signal intensity with varying concentrations of methemoglobin and a contrast relationship similar to T2-weighted spin-echo techniques. FISP and FLASH showed intensity changes at lower concentrations of ferromagnetic material than T2-weighted spin-echo sequences. In vitro blood clot was less intense when observed by FISP and FLASH sequences than on the T2-weighted spin-echo sequences. Maximum contrast between clot and other blood components occurred at a flip andle of 45° for FLASH and 60° for FISP. FISP and FLASH scans of patients with hemorrhage demonstrated a marked decrease in signal intensity in the region of blood clot. This decrease was more pronounced with the gradient-echo sequences than with T2-weighted spin-echo images. We conclude that FLASH is useful for detecting methemoglobin and that both FISP and FLASH are useful for evaluating hemorrhage because of their sensitivity to methemoglobin.

Original languageEnglish (US)
Pages (from-to)163-172
Number of pages10
JournalMagnetic Resonance Imaging
Volume7
Issue number2
DOIs
StatePublished - 1989

Fingerprint

hemorrhages
Methemoglobin
echoes
Blood
Hemorrhage
Imaging techniques
gradients
Thrombosis
blood
Ferromagnetic materials
Magnetization
interleukin-24
ferromagnetic materials
precession
serums
low concentrations
Serum
magnetization

Keywords

  • FISP
  • FLASH
  • Gradient-echo imaging
  • Hemorrhage

ASJC Scopus subject areas

  • Biophysics
  • Clinical Biochemistry
  • Structural Biology
  • Radiology Nuclear Medicine and imaging
  • Condensed Matter Physics

Cite this

Gradient-echo imaging of hemorrhage at 1.5 Tesla. / Unger, Evan C; Cohen, Mark S.; Brown, Truman R.

In: Magnetic Resonance Imaging, Vol. 7, No. 2, 1989, p. 163-172.

Research output: Contribution to journalArticle

Unger, Evan C ; Cohen, Mark S. ; Brown, Truman R. / Gradient-echo imaging of hemorrhage at 1.5 Tesla. In: Magnetic Resonance Imaging. 1989 ; Vol. 7, No. 2. pp. 163-172.
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