Growth factor receptors as targets for therapy in pediatric brain tumors

Emmanuelle Meuillet, Eric G. Bremer

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Growth factor receptors (GFRs) have been described as overexpressed in several types of brain tumors. Overexpression of these transmembrane proteins is considered to be an important part of tumorigenesis. Genetic as well as epigenetic modulation of the receptors have to be considered when trying to understand the role of GFRs in tumors or as targets for tumor therapy. GFR function can be modulated by membrane components (e:g. gangliosides) or by the change in receptor glycosylation. These types of changes and the occurrence of the expression of mutated receptor expressed in tumor cell can result in altered signaling. In this review, we have focused on GFRs, their expression and mutations in brain tumors. Recently the correlation between GFR expression and patient outcome has suggested that these tyrosine kinases and their signaling might play a decisive role in the course of patients with brain tumors. The importance of GFRs as possible targets for brain tumor therapy is also discussed.

Original languageEnglish (US)
Pages (from-to)1-13
Number of pages13
JournalPediatric Neurosurgery
Volume29
Issue number1
DOIs
StatePublished - 1998
Externally publishedYes

Fingerprint

Growth Factor Receptors
Brain Neoplasms
Pediatrics
Therapeutics
Neoplasms
Gangliosides
Glycosylation
Epigenomics
Protein-Tyrosine Kinases
Carcinogenesis
Mutation
Membranes
Proteins

Keywords

  • Brain tumor
  • Ganglioside
  • Glycosylation
  • Growth factor
  • Receptor tyrosine kinase

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

Cite this

Growth factor receptors as targets for therapy in pediatric brain tumors. / Meuillet, Emmanuelle; Bremer, Eric G.

In: Pediatric Neurosurgery, Vol. 29, No. 1, 1998, p. 1-13.

Research output: Contribution to journalArticle

@article{d08c880beb6e41b3a9ac88eb93b6a1e0,
title = "Growth factor receptors as targets for therapy in pediatric brain tumors",
abstract = "Growth factor receptors (GFRs) have been described as overexpressed in several types of brain tumors. Overexpression of these transmembrane proteins is considered to be an important part of tumorigenesis. Genetic as well as epigenetic modulation of the receptors have to be considered when trying to understand the role of GFRs in tumors or as targets for tumor therapy. GFR function can be modulated by membrane components (e:g. gangliosides) or by the change in receptor glycosylation. These types of changes and the occurrence of the expression of mutated receptor expressed in tumor cell can result in altered signaling. In this review, we have focused on GFRs, their expression and mutations in brain tumors. Recently the correlation between GFR expression and patient outcome has suggested that these tyrosine kinases and their signaling might play a decisive role in the course of patients with brain tumors. The importance of GFRs as possible targets for brain tumor therapy is also discussed.",
keywords = "Brain tumor, Ganglioside, Glycosylation, Growth factor, Receptor tyrosine kinase",
author = "Emmanuelle Meuillet and Bremer, {Eric G.}",
year = "1998",
doi = "10.1159/000028677",
language = "English (US)",
volume = "29",
pages = "1--13",
journal = "Pediatric Neurosurgery",
issn = "1016-2291",
publisher = "S. Karger AG",
number = "1",

}

TY - JOUR

T1 - Growth factor receptors as targets for therapy in pediatric brain tumors

AU - Meuillet, Emmanuelle

AU - Bremer, Eric G.

PY - 1998

Y1 - 1998

N2 - Growth factor receptors (GFRs) have been described as overexpressed in several types of brain tumors. Overexpression of these transmembrane proteins is considered to be an important part of tumorigenesis. Genetic as well as epigenetic modulation of the receptors have to be considered when trying to understand the role of GFRs in tumors or as targets for tumor therapy. GFR function can be modulated by membrane components (e:g. gangliosides) or by the change in receptor glycosylation. These types of changes and the occurrence of the expression of mutated receptor expressed in tumor cell can result in altered signaling. In this review, we have focused on GFRs, their expression and mutations in brain tumors. Recently the correlation between GFR expression and patient outcome has suggested that these tyrosine kinases and their signaling might play a decisive role in the course of patients with brain tumors. The importance of GFRs as possible targets for brain tumor therapy is also discussed.

AB - Growth factor receptors (GFRs) have been described as overexpressed in several types of brain tumors. Overexpression of these transmembrane proteins is considered to be an important part of tumorigenesis. Genetic as well as epigenetic modulation of the receptors have to be considered when trying to understand the role of GFRs in tumors or as targets for tumor therapy. GFR function can be modulated by membrane components (e:g. gangliosides) or by the change in receptor glycosylation. These types of changes and the occurrence of the expression of mutated receptor expressed in tumor cell can result in altered signaling. In this review, we have focused on GFRs, their expression and mutations in brain tumors. Recently the correlation between GFR expression and patient outcome has suggested that these tyrosine kinases and their signaling might play a decisive role in the course of patients with brain tumors. The importance of GFRs as possible targets for brain tumor therapy is also discussed.

KW - Brain tumor

KW - Ganglioside

KW - Glycosylation

KW - Growth factor

KW - Receptor tyrosine kinase

UR - http://www.scopus.com/inward/record.url?scp=0032449010&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032449010&partnerID=8YFLogxK

U2 - 10.1159/000028677

DO - 10.1159/000028677

M3 - Article

VL - 29

SP - 1

EP - 13

JO - Pediatric Neurosurgery

JF - Pediatric Neurosurgery

SN - 1016-2291

IS - 1

ER -