Growth hormone secretion in Prader-Willi syndrome

H. Costeff, V. A. Holm, R. Ruvalcaba, Joan L Shaver

Research output: Contribution to journalArticle

80 Citations (Scopus)

Abstract

Integrated 12-hour growth hormone secretion studies, peak growth hormone response to clonidine provocation. Somatomedin-C levels, T-4 and TSH levels were studied in six growth-retarded children with the Prader-Willi syndrome, of whom five had a 15 q-karyotype. Only one of the subjects was obese. All showed abnormally low growth hormone secretion. None achieved a nocturnal peak above 10 μg/l, none had a mean nocturnal level over 1.8, and none showed a level above 8 μg/l after clonidine provocation. These findings contrasted with normal TSH in all and normal T-4 in five. These findings suggest that the poor linear growth in the Prader-Willi syndrome is caused by a true deficiency of growth hormone secretion, and that the low growth hormone levels observed in such cases are not an artifact of obesity.

Original languageEnglish (US)
Pages (from-to)1059-1062
Number of pages4
JournalActa Paediatrica Scandinavica
Volume79
Issue number11
StatePublished - 1990
Externally publishedYes

Fingerprint

Prader-Willi Syndrome
Growth Hormone
Clonidine
Growth
Insulin-Like Growth Factor I
Karyotype
Artifacts
Obesity

Keywords

  • growth hormone 12-hour integrated study
  • hypostature
  • Prader-Willi syndrome
  • thyroid function

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Costeff, H., Holm, V. A., Ruvalcaba, R., & Shaver, J. L. (1990). Growth hormone secretion in Prader-Willi syndrome. Acta Paediatrica Scandinavica, 79(11), 1059-1062.

Growth hormone secretion in Prader-Willi syndrome. / Costeff, H.; Holm, V. A.; Ruvalcaba, R.; Shaver, Joan L.

In: Acta Paediatrica Scandinavica, Vol. 79, No. 11, 1990, p. 1059-1062.

Research output: Contribution to journalArticle

Costeff, H, Holm, VA, Ruvalcaba, R & Shaver, JL 1990, 'Growth hormone secretion in Prader-Willi syndrome', Acta Paediatrica Scandinavica, vol. 79, no. 11, pp. 1059-1062.
Costeff, H. ; Holm, V. A. ; Ruvalcaba, R. ; Shaver, Joan L. / Growth hormone secretion in Prader-Willi syndrome. In: Acta Paediatrica Scandinavica. 1990 ; Vol. 79, No. 11. pp. 1059-1062.
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