Growth-related signaling as a target of toxic insult in vascular smooth muscle cells: Implications in atherogenesis

Kenneth S. Ramos, Alan R. Parrish

Research output: Contribution to journalShort surveypeer-review

23 Scopus citations

Abstract

Aberrant smooth muscle cell proliferation is a focal point in the genesis and progression of atherosclerosis. To date, limited information is available on the molecular and cellular basis of the atherogenic response and the potential contribution of environmental chemicals to the overall process. This review highlights major findings in this laboratory on the mechanism(s) responsible for the acquisition of a proliferative phenotype in vascular smooth muscle cells following repeated cycles of treatment with allylamine and benzo(a)pyrene, known atherogenic chemicals. These agents share the ability to induce and promote aberrant proliferative behavior in smooth muscle cells, but appear to interfere with distinct molecular targets.

Original languageEnglish (US)
Pages (from-to)627-635
Number of pages9
JournalLife Sciences
Volume57
Issue number7
DOIs
StatePublished - Jul 7 1995
Externally publishedYes

Keywords

  • allylamine
  • benzo(a)pyrene
  • extracellular matrix
  • growth factors
  • protein kinase C
  • proto-oncogenes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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